Amyloidosis - Amyloidose
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Klassesch Gesiichtsmerkmale vun Amyloidose (Amyloidosis)
References
Eng 26 Joer al Fra ass bei eis Klinik komm an huet sech beschwéiert iwwer e Jucken Ausschlag op de Been, deen si säit 10 Joer hat. Trotz der Benotzung vun Steroidcremen an Tazarotin Creme, ass den Ausschlag net besser ginn. Si huet keng relevant Famill Geschicht. Wéi mir si ënnersicht hunn, hu mir opgehuewe, rau Flecken op der viischter Säit vun hire Been fonnt, déi mat enger Krankheet mam Numm lichen amyloidosis passen.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis ass e rare Hautzoustand verbonne mat persistent Jucken vun onbekannter Ursaach. Et weist sech normalerweis als Cluster vun opgehuewe, verfärbte Flecken op de baussenzegen Uewerflächen vun der Haut. Lichen Amyloidosis erschéngt normalerweis bei Leit vu 50 bis 60 Joer a leider gëtt et keng Heelung dofir. Behandlungen, déi elo verfügbar sinn, funktionnéieren normalerweis net gutt.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis ass e laang dauerhafte Jucken Haut Zoustand. Et ass bekannt fir Cluster vu verdickten Bumpen haaptsächlech um Réck, Schanken, Oberschenkel a Waffen. Wann ënner engem Mikroskop ënnersicht, Lichen amyloidosis weist en Opbau vun Amyloid an der ieweschter Hautschicht zesumme mat Verdickung an Erweiderung vun der äusserer Hautschicht. Och wann déi genee Ursaach vum Lichen amyloidosis nach net ganz verstanen ass, hu fréier Studien et u Faktore verbonne wéi Reibung oder Reibung op der Haut, Zell Doud, Viral Infektiounen, ënner anerem. Lichen amyloidosis schéngt mat verschiddenen anere Hautbedéngungen verbonnen ze sinn (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnos a Behandlung
#Electrophoresis of blood or urine
#Skin biopsy