Dysplastic nevus - Dysplastesche Nevus
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Dysplastic nevi ― Biopsie gëtt fir Westerner recommandéiert.
References
Dysplastic nevus , och bekannt als atypesch oder Clarks nevus, huet Debatten an der Dermatologie an der Dermatopathologie ausgeléist. Dokteren Biopsie dacks dës Moles well se anormal ausgesinn a Bedenken iwwer Melanom erhéijen.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , och bekannt als atypesch oder Clark Nevi, kann heiansdo zu Melanom féieren. Ongeféier 36% vun de Melanome gi bei dysplastesche Nevi fonnt. Unzeeche datt en dysplastesche Nevus zu Melanom verwandelen kann, enthalen ongläiche Form, méi Pigmentännerungen oder eng groer Faarf. Dës Cancers geschéien normalerweis an engem méi jonken Alter (ronn d'Mëtt vun den Drëssegjärege) , kënne multiple sinn a sinn dacks um Stamm. Genetesch sinn dysplastic nevi tëscht benign Nevi a Melanom. Allerdéngs kommen nëmmen 20% bis 30% vun de Melanome aus existéierenden Nevi. Well déi meescht Nevi kee Melanom ginn, ass et normalerweis net recommandéiert se präventiv ze läschen.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
E Melanom ass eng Zort Tumor, déi sech formt wann Melanocyten, Zellen verantwortlech fir Hautfaarf, kriibserreegend ginn. Melanozyten entstinn aus dem neuralen Kamm. Dëst bedeit datt Melanome sech net nëmmen op der Haut entwéckelen kënnen, awer och an anere Beräicher, wou neural Kammzellen migréieren, wéi de Magen-Darmtrakt a Gehir. D'Iwwerliewensquote fir Patiente mat fréizäiteg Melanom (Stage 0) ass héich bei 97%, während se wesentlech op ongeféier 10% fällt fir déi diagnostizéiert mat fortgeschrattene Stadium Krankheet (Stage IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Kriibsrisiko
Wéi bei kaukaseschen Individuen an den USA gesi ginn, hunn déi mat dysplastesche Nevi e Liewensdauer Risiko fir Melanom vu méi wéi 10% z'entwéckelen. Op der anerer Säit hunn déi ouni dysplastesche Nevus e Risiko fir Melanom vu manner wéi 1% z'entwéckelen.
○ Precautioun fir Individuen mat dysplasteschen Nevi
Haut Selbstuntersuchung gëtt normalerweis empfohlen fir Melanom ze vermeiden (duerch d'Identifikatioun vun atypesche Nevi, déi ewechgeholl kënne ginn) oder fir fréizäiteg Detektioun vun existente Tumoren. Leit mat enger perséinlecher oder familiärer Geschicht vu Hautkriibs oder vu multiplen atypeschen Nevi sollten op d'mannst eemol d'Joer en Dermatologe gesinn fir sécher ze sinn datt se kee Melanom entwéckelen.
D'Ofkierzung [ABCDE] war nëtzlech fir Gesondheetsversuerger a Laie ze hëllefen d'Schlësselcharakteristike vun engem Melanom z'erënneren. Leider fir déi duerchschnëttlech Persoun, vill seborrheesch Keratosen, e puer lentigo senilis, a souguer Warzen kënnen [ABCDE] Charakteristiken hunn, a kënnen net vun engem Melanom ënnerscheeden.
○ [ABCDE]
Asymmetrical: Asymmetresch Hautlässioun.
Border: D'Grenz vun der Läsion ass onregelméisseg.
Color: Melanome hunn normalerweis méi onregelméisseg Faarwen.
Diameter: Nevi méi wéi 6 mm si méi wahrscheinlech Melanome wéi méi kleng Nevi.
Evolution: D'Evolutioun (dh Ännerung) vun engem Nevus oder Läsion kann uginn datt d'Läsioun bösarteg gëtt.