Erythema multiforme
☆ An den 2022 Stiftung Warentest Resultater aus Däitschland war d'Zefriddenheet vum Konsument mam ModelDerm nëmme liicht manner wéi mat bezuelte Telemedizin Konsultatiounen.
Erythema multiforme minor ― Notéiert datt d'Zentren vun de Läsionen blanchéieren kënnen.
Urticaria kann och als Differentialdiagnos ugesi ginn.
References
Erythema multiforme (EM) ass eng Bedingung wou markéiert Zil-ähnlech Flecken souwuel op der Haut wéi och op der Schleimhaut optrieden wéinst Immunreaktiounen. Och wann dacks duerch virale Infektiounen ausgeléist gëtt, besonnesch Herpes Simplex Virus (HSV) , oder bestëmmte Medikamenter, bleift d'Ursaach a ville Fäll onbekannt. D'Behandlung vun akuter EM konzentréiert sech op d'Erliichterung vun de Symptomer mat Cremen déi Steroiden oder Antihistaminle enthalen. D'Verwaltung vun widderhuelend EM ass am effektivsten wann se op all Patient ugepasst sinn. Déi initial Approche beinhalt souwuel mëndlech wéi topesch Behandlungen. Dës enthalen Corticosteroiden an antiviral Medikamenter. Topesch Behandlungen besteet aus staarken Steroidcremen a Léisunge fir betroffene Schleimhäute. Fir Patienten, déi net op Antivirale reagéieren, enthalen Second-Line Optiounen immun-ënnerdréckend Medikamenter, Antibiotike, Anthelmintika, an Antimalaria.
Erythema multiforme (EM) is an immune-mediated condition that classically presents with discrete targetoid lesions and can involve both mucosal and cutaneous sites. While EM is typically preceded by viral infections, most notably herpes simplex virus (HSV), and certain medications, a large portion of cases are due to an unidentifiable cause. Treatment for acute EM is focused on relieving symptoms with topical steroids or antihistamines. Treatment for recurrent EM is most successful when tailored to individual patients. First line treatment for recurrent EM includes both systemic and topical therapies. Systemic therapies include corticosteroid therapy and antiviral prophylaxis. Topical therapies include high-potency corticosteroids, and antiseptic or anesthetic solutions for mucosal involvement. Second-line therapies for patients who do not respond to antiviral medications include immunosuppressive agents, antibiotics, anthelmintics, and antimalarials
Erythema multiforme (EM) is an immune-mediated condition that classically presents with discrete targetoid lesions and can involve both mucosal and cutaneous sites. While EM is typically preceded by viral infections, most notably herpes simplex virus (HSV), and certain medications, a large portion of cases are due to an unidentifiable cause. Treatment for acute EM is focused on relieving symptoms with topical steroids or antihistamines. Treatment for recurrent EM is most successful when tailored to individual patients. First line treatment for recurrent EM includes both systemic and topical therapies. Systemic therapies include corticosteroid therapy and antiviral prophylaxis. Topical therapies include high-potency corticosteroids, and antiseptic or anesthetic solutions for mucosal involvement. Second-line therapies for patients who do not respond to antiviral medications include immunosuppressive agents, antibiotics, anthelmintics, and antimalarials
A ville Fäll geet mëll erythema multiforme eleng bannent 2 bis 4 Wochen. Stevens-Johnson Syndrom, e schwéieren Zoustand, deen d'Schleimhäute beaflosst, kann bis zu 6 Wochen daueren. Steroiden sinn net typesch fir mëll Fäll recommandéiert. Ob Steroiden solle fir schwéieren Erythema multiforme benotzt ginn ass ongewëss, well et keng kloer Erkenntnisser aus randomiséierter Studien sinn, déi uginn, wéi eng Kanner vun dëser Behandlung profitéieren.
In most cases, mild erythema multiforme is self-limited and resolves in 2 to 4 weeks. Stevens-Johnson syndrome is a serious disease that involves the mucous membranes and lasts up to 6 weeks. There is no indication for using steroids for the mild form. Use of steroids for erythema multiforme major is debatable because no randomized studies clearly indicate which children will benefit from this treatment.
In most cases, mild erythema multiforme is self-limited and resolves in 2 to 4 weeks. Stevens-Johnson syndrome is a serious disease that involves the mucous membranes and lasts up to 6 weeks. There is no indication for using steroids for the mild form. Use of steroids for erythema multiforme major is debatable because no randomized studies clearly indicate which children will benefit from this treatment.
Mir presentéieren e Fall vun mëndlechen erythema multiforme (EM) verursaacht duerch TMP/SMX , weist typesch mëndlech a Lip ulcers ouni Haut lesions. Dëst ënnersträicht d'Noutwennegkeet et vun anere mëndleche ulcerative Stéierungen ze differenzéieren. De Patient krut symptomatesch Behandlung a Prednisolon-Tabletten, wat zu enger Verbesserung féiert nodeems d'TMP/SMX-Therapie gestoppt gouf.
We report a case of oral erythema multiforme (EM) secondary to TMP/SMX that presented with oral and lip ulcerations typical of EM without any skin lesions and highlights the importance of distinguishing them from other ulcerative disorders involving oral cavity. The patient was treated symptomatically and given tablet prednisolone. The condition improved with stoppage of TMP/SMX therapy.
We report a case of oral erythema multiforme (EM) secondary to TMP/SMX that presented with oral and lip ulcerations typical of EM without any skin lesions and highlights the importance of distinguishing them from other ulcerative disorders involving oral cavity. The patient was treated symptomatically and given tablet prednisolone. The condition improved with stoppage of TMP/SMX therapy.
Erythema multiforme ass eng Reaktioun mat der Haut an heiansdo der Schleimhaut, ausgeléist vum Immunsystem. Typesch manifestéiert et sech als Zil-ähnleche Läsionen, déi isoléiert kënne schéngen, widderhuelen oder bestoe bleiwen. Dës Läsionen beaflossen normalerweis symmetresch d'Extremitéiten, besonnesch hir baussenzeg Uewerfläch. D'Haaptursaachen enthalen Infektiounen wéi Herpes Simplex Virus a Mycoplasma pneumoniae, souwéi verschidde Medikamenter, Immunisatiounen an Autoimmunerkrankungen. D'Ënnerscheedung erythema multiforme vun Urtikaria hänkt vun der Dauer vun de Läsionen of; erythema multiforme Läsionen bleiwen op d'mannst siwe Deeg fixéiert, während urticarial Läsionen dacks bannent engem Dag verschwannen. Och wann et ähnlech ass, ass et entscheedend erythema multiforme vum méi schwéiere Stevens-Johnson Syndrom ze differenzéieren, wat typesch verbreet erythematös oder purpuresch Makule mat Bléiser presentéiert. Gestioun erythema multiforme involvéiert symptomatesch Erliichterung mat topeschen Steroiden oder Antihistaminle a adresséiert déi ënnerierdesch Ursaach. Fir widderhuelende Fäll, déi mam Herpes Simplex Virus verbonne sinn, gëtt prophylaktesch antiviral Therapie recommandéiert. Schwéier Schleimhaut Engagement kann Hospitalisatioun fir intravenös Flëssegkeeten an Elektrolyt Ersatz erfuerderen.
Erythema multiforme is a reaction involving the skin and sometimes the mucosa, triggered by the immune system. Typically, it manifests as target-like lesions, which may appear isolated, recur, or persist. These lesions usually symmetrically affect the extremities, particularly their outer surfaces. The main causes include infections like herpes simplex virus and Mycoplasma pneumoniae, as well as certain medications, immunizations, and autoimmune diseases. Distinguishing erythema multiforme from urticaria relies on the duration of lesions; erythema multiforme lesions remain fixed for at least seven days, while urticarial lesions often vanish within a day. Although similar, it's crucial to differentiate erythema multiforme from the more severe Stevens-Johnson syndrome, which typically presents widespread erythematous or purpuric macules with blisters. Managing erythema multiforme involves symptomatic relief with topical steroids or antihistamines and addressing the underlying cause. For recurrent cases associated with herpes simplex virus, prophylactic antiviral therapy is recommended. Severe mucosal involvement may necessitate hospitalization for intravenous fluids and electrolyte replacement.
Erythema multiforme is a reaction involving the skin and sometimes the mucosa, triggered by the immune system. Typically, it manifests as target-like lesions, which may appear isolated, recur, or persist. These lesions usually symmetrically affect the extremities, particularly their outer surfaces. The main causes include infections like herpes simplex virus and Mycoplasma pneumoniae, as well as certain medications, immunizations, and autoimmune diseases. Distinguishing erythema multiforme from urticaria relies on the duration of lesions; erythema multiforme lesions remain fixed for at least seven days, while urticarial lesions often vanish within a day. Although similar, it's crucial to differentiate erythema multiforme from the more severe Stevens-Johnson syndrome, which typically presents widespread erythematous or purpuric macules with blisters. Managing erythema multiforme involves symptomatic relief with topical steroids or antihistamines and addressing the underlying cause. For recurrent cases associated with herpes simplex virus, prophylactic antiviral therapy is recommended. Severe mucosal involvement may necessitate hospitalization for intravenous fluids and electrolyte replacement.
D'Conditioun variéiert vun engem mëllen, selbstbegrenzten Ausschlag zu enger schwéierer, liewensgeféierlecher Form bekannt als Erythema multiforme major, déi och Schleimhaut involvéiert. Invasioun vun der Schleimhaut oder d'Präsenz vu Bullen si wichteg Zeeche vun der Schwéierkraaft.
- Erythema multiforme minor: typesch Ziler oder opgehuewe, edematous papules verdeelt acrally
Déi mëll Form stellt normalerweis mat liicht Jucken (awer Jucken kann ganz schwéier sinn), rosa-rout Flecken, symmetresch arrangéiert a fänkt un den Extremitéiten un. D'Resolutioun vum Ausschlag bannent 7-10 Deeg ass d'Norm an dëser Form vun der Krankheet.
- Erythema multiforme major: typesch Ziler oder opgehuewe, edematöse Papelen verdeelt akraal mat Bedeelegung vun enger oder méi Schleimhäute. Epidermal Detachement involvéiert manner wéi 10% vun der Gesamtkierperfläch.
○ Behandlung ― OTC Drogen
Wann et mat engem Féiwer begleet gëtt (steigend Kierpertemperatur), ass et recommandéiert d'Spidol sou séier wéi méiglech ze besichen.
Verdächtegt Drogen solle gestoppt ginn. (zB Antibiotike, net-steroidal anti-inflammatoresch Medikamenter)
Oral Antihistaminle wéi Cetirizin a Loratadin fir Jucken.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]