Herpes simplex
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Herpes Simplex op der Lip.
Herpes simplex ― Herpes Simplex Infektioun an de Fanger ass méi heefeg bei jonke Kanner wéi bei Erwuessener.
References
HSV-1 Infektioun progresséiert duerch primär Infektioun vun Epithelzellen, gefollegt vun Latenz, haaptsächlech an Neuronen, a Reaktivéierung. HSV-1 verursaacht allgemeng initial a widderhuelend vesikulär Ausbréch, haaptsächlech op de Mond an der Genitalmucosa. Seng Manifestatiounen reichen vun orolabial Herpes op verschidde Konditiounen wéi herpetesch Folliculitis, Hautinfektiounen, Okulär Bedeelegung, a schwéiere Fäll wéi Herpes Ensephalitis. Antiviral Therapie hëlleft HSV Infektioun ze managen.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 2 (HSV-2) ass eng verbreet Infektioun, déi ongeféier 22% vun Erwuessener vun 12 Joer a méi beaflosst, am Ganzen 45 Milliounen Erwuessener an den USA. Wärend HSV-1 typesch mëndlech Wounds verursaacht, kann et och zu Genitalläsiounen féieren. Wéi och ëmmer, wann d'Patienten genital Läsionen hunn, ass HSV-2 normalerweis d'Haaptsuerg. D'Symptomer vun HSV-2 Ausbroch sinn dacks vague, wéi Genital Jucken an Reizung, wat d'Diagnostik an d'Behandlung verspéiten. Dës Verzögerung kann zu enger weiderer Iwwerdroung un oninfizéierte Leit féieren.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus (HSV) verursaacht allgemeng Infektiounen wéi genital Herpes an Erkältung bei Teenager an Erwuessener. Wann HSV e Puppelchen an den éischte 4-6 Woche vum Liewen infizéiert, kann et zu enger schwéierer Krankheet mat eeschte Konsequenzen féieren. Schnell diagnostizéiert neonatal HSV Infektioun ass entscheedend fir d'Krankheet ze stoppen fir verschlechtert ze ginn, neurologesch Themen ze vermeiden (och Doud) .
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex Infektioun ass ganz heefeg a ka vu schwangere Fraen op hir Puppelcher iwwerginn. Dëse Virus kann sérieux Gesondheetsprobleemer oder souguer Doud bei Neigebueren verursaachen. Obwuel et selten während der Schwangerschaft selwer ass, geschitt et dacks während der Gebuert. De Risiko ass héchst wann d'Mamm an de spéidere Stadien vun der Schwangerschaft infizéiert gëtt. Wéi och ëmmer, dëse Risiko kann reduzéiert ginn andeems Dir antiviral Medikamenter benotzt oder a bestëmmte Situatiounen eng C-Sektioun entscheet.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Herpes simplex virus (HSV) Typen 1 an 2 infizéieren vill Leit weltwäit. Normalerweis bleift de Virus roueg an den Nervenzellen nodeems se d'Haut infizéiert hunn, awer et kann spéider reaktivéieren, a verursaache Kale Geschwëster. Heiansdo féiert et zu schwéiere Probleemer wéi Aen Infektiounen, Gehirentzündung oder geféierlech Konditiounen bei Neigebuerenen a Leit mat schwaachem Immunsystem. Wärend déi aktuell Medikamenter hëllefen Infektiounen ze kontrolléieren, bleift de Risiko vun Drogenresistenz an Nebenwirkungen eng Suerg. Mir brauchen nei Medikamenter fir de Virus besser ze zielen.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Et ginn zwou Zorte vu herpes simplex Virus, Typ 1 (HSV-1) an Typ 2 (HSV-2). HSV-1 verursaacht méi heefeg Infektiounen ronderëm de Mond, während HSV-2 méi heefeg Genital Infektiounen verursaacht. Si ginn duerch direkte Kontakt mat der infizéierter Persoun iwwerdroen. Genital Herpes gëtt als sexuell iwwerdroen Infektioun klasséiert. Et kann op e Puppelchen während der Gebuert verbreet ginn. No der Infektioun ginn d'Viren laanscht sensoresch Nerven an d'Nervezellkierper transportéiert, wou se liewenslaang wunnen. Ursaache vum Widderhuelung kënnen enthalen: Ofsenkung vun der Immunfunktioun, Stress a Sonneliichtbelaaschtung.
In de meeschte Fäll ginn antiviral Medikamenter nëmmen geholl wann d'Symptomer schwéier sinn. All Dag antiviral Medikamenter kënne fir een verschriwwen ginn, deen eng ganz heefeg Infektioun huet. Et gëtt keng Impfung verfügbar an d'Shingles Impfung verhënnert net Herpes Simplex. Behandlungen mat antiviralen Medikamenter wéi Aciclovir oder Valaciclovir kënnen d'Gravitéit vun de Symptomer reduzéieren.
Weltwäit Tariffer vun entweder HSV-1 oder HSV-2 sinn tëscht 60% an 95% bei Erwuessener. HSV-1 ass normalerweis während der Kandheet infizéiert. Eng geschätzte 536 Millioune Leit weltwäit (16% vun der Bevëlkerung) ware mat HSV-2 infizéiert wéi 2003 mat méi héijen Tauxe bei Fraen an deenen an den Entwécklungslänner. Déi meescht Leit mat HSV-2 realiséieren net datt se infizéiert sinn.
○ Behandlung ― OTC Drogen
Vermeit all kierperleche Kontakt, wéi zum Beispill e Kand ze kussen, während d'Bléiser präsent sinn, well de Kontakt d'Infektioun op aner Leit verbreet kann. Dir sollt raschten ouni Alkohol ze drénken.
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