Porokeratosis - Porokeratose
☆ An den 2022 Stiftung Warentest Resultater aus Däitschland war d'Zefriddenheet vum Konsument mam ModelDerm nëmme liicht manner wéi mat bezuelte Telemedizin Konsultatiounen.
Déi haart ausstehend Kanten sinn charakteristesch.
References
Porokeratosis ass e seltenen Hautzoustand, charakteriséiert duerch Keratiniséierungsproblemer, wat zu opgehuewe, ringfërmege Flecken oder raue Knollen op der Haut resultéiert. Seng definéierend Feature ënner dem Mikroskop ass d'Präsenz vu Cornoid Lamellen, eng spezifesch Arrangement vun Zellen an der ieweschter Schicht vun der Haut. Porokeratosis kënnt a verschiddene Formen (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Et ass wichteg ze notéieren datt porokeratosis sech potenziell zu Hautkriibs entwéckelen kann. De beschte Wee fir porokeratosis ze diagnostizéieren ass duerch eng Biopsie vun der opgehuewe Grenz, obwuel et de Moment kee Standardbehandlungsprotokoll gëtt.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) ass eng Krankheet vu gestéierter Keratiniséierung. Et ass eng vu sechs Aarte vu Porokeratose, an et beaflosst typesch méi grouss Flächen am Verglach mat deenen aneren (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Déi eruptiv Aart vu Porokeratose verbënnt dacks mat Kriibs, geschwächt Immunitéit oder Entzündung. Risikofaktoren beinhalt d'Genetik, d'Immununterdréckung an d'Sonnebelaaschtung. DSAP fänkt als rosa oder brong Knollen mat opgehuewe Kanten a Sonneliicht ausgesatem Gebidder un, heiansdo verursaache liicht Jucken. Behandlungen variéieren a kënnen topesch Cremes, Liichttherapie oder Medikamenter wéi 5-Fluorouracil oder Retinoiden enthalen. Dës Läsionen ginn als precancerous ugesinn, mat enger 7. 5 - 10 % Chance fir zu Plateauzell- oder Basalzellkarzinom ze verwandelen.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
En 52 Joer ale Mann, virdru gesond, koum mat engem flaache, ringfërmege Fleck um Enn vu senger véierter Zeh era, deen zënter 2 Joer do war ouni Symptomer ze verursaachen. Et huet ugefaang als e klengen, haarde Bump an ass mat der Zäit no baussen gewuess. Trotz verschiddenen Behandlungen probéiert wéi Kryotherapie, Cremes, Antimykotika an Antibiotike, ass de Patch net besser ginn. D'Untersuchung et enk mat enger Dermocopsie huet e trocken, roude Zentrum mat enger décker, rauer Grenz gewisen. E klengt Stéck Haut, dat vum Rand vum Fleck geholl gouf, huet anormalen Zellwachstum an der äusserer Schicht vun der Haut gewisen, wat eng Diagnostik porokeratosis of Mibelli bestätegt.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Oft gëtt eng Biopsie gemaach, well et kann ähnlech wéi aktinesch Keratose oder Plateauzellkarzinom ausgesinn.