ຂໍ້ມູນເພີ່ມເຕີມ ― Lao

ແມ່ຍິງອາຍຸ 26 ປີໄດ້ມາຄລີນິກຂອງພວກເຮົາຈົ່ມວ່າມີອາການຄັນຢູ່ຂາທີ່ລາວເປັນມາເປັນເວລາ 10 ປີ. ເຖິງວ່າຈະມີການໃຊ້ຄີມ steroid ແລະຄີມ tazarotene, ຜື່ນບໍ່ດີຂຶ້ນ. ນາງບໍ່ມີປະຫວັດຄອບຄົວທີ່ກ່ຽວຂ້ອງ. ​ເມື່ອ​ເຮົາ​ກວດ​ເບິ່ງ​ນາງ, ພວກ​ເຮົາ​ໄດ້​ພົບ​ເຫັນ​ຮອຍ​ຫຍາບ​ຢູ່​ດ້ານ​ໜ້າ​ຂາ​ຂອງ​ນາງ, ຊຶ່ງ​ກົງ​ກັບ​ພະຍາດ​ທີ່​ເອີ້ນ​ວ່າ lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.

Lichen Amyloidosis ເປັນສະພາບຜິວໜັງທີ່ຫາຍາກຕິດພັນກັບອາການຄັນຢ່າງຕໍ່ເນື່ອງໂດຍບໍ່ຮູ້ສາເຫດ. ໂດຍປົກກະຕິມັນສະແດງເປັນກຸ່ມທີ່ຍົກຂຶ້ນມາ, ມີຈຸດປ່ຽນສີຢູ່ດ້ານນອກຂອງຜິວໜັງ. Lichen Amyloidosis ມັກຈະປະກົດຢູ່ໃນຄົນອາຍຸ 50 ຫາ 60 ປີ ແລະໜ້າເສຍດາຍ, ບໍ່ມີການປິ່ນປົວໃຫ້ໄດ້. ການປິ່ນປົວທີ່ມີຢູ່ໃນປັດຈຸບັນມັກຈະເຮັດວຽກບໍ່ດີ.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.

Lichen amyloidosis ເປັນສະພາບຜິວໜັງທີ່ຕິດທົນນານ. ມັນເປັນທີ່ຮູ້ຈັກສໍາລັບກຸ່ມຂອງຕໍາທີ່ຫນາແຫນ້ນທີ່ພົບເຫັນສ່ວນໃຫຍ່ຢູ່ດ້ານຫລັງ, shins, ຕົ້ນຂາ, ແລະແຂນ. ເມື່ອກວດສອບພາຍໃຕ້ກ້ອງຈຸລະທັດ, Lichen amyloidosis ສະແດງໃຫ້ເຫັນເຖິງການສ້າງຂອງ amyloid ໃນຊັ້ນເທິງຂອງຜິວຫນັງພ້ອມກັບການຫນາແຫນ້ນແລະການຂະຫຍາຍຂອງຊັ້ນຜິວຫນັງຊັ້ນນອກ. ເຖິງແມ່ນວ່າສາເຫດທີ່ແນ່ນອນຂອງ Lichen amyloidosis ຍັງບໍ່ທັນເຂົ້າໃຈຢ່າງເຕັມສ່ວນ, ການສຶກສາທີ່ຜ່ານມາໄດ້ເຊື່ອມໂຍງມັນກັບປັດໃຈຕ່າງໆເຊັ່ນ: ການຖູຫຼື friction ຜິວຫນັງ, ການເສຍຊີວິດຂອງເຊນ, ການຕິດເຊື້ອໄວຣັດ, ແລະອື່ນໆ. Lichen amyloidosis ເບິ່ງ​ຄື​ວ່າ​ຕິດ​ພັນ​ກັບ​ສະ​ພາບ​ຜິວ​ຫນັງ​ອື່ນໆ​ຈໍາ​ນວນ​ຫນຶ່ງ (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.