Angiofibromas are small, reddish brown or even flesh-colored, smooth, shiny, 0.1 to 0.3 cm papules present over the sides of the nose and the medial portions of the cheeks. They contain fibrous tissue.
Cutaneous angiofibromas ສາມາດປາກົດຢູ່ໃນສ່ວນຕ່າງໆຂອງຮ່າງກາຍ. ຢູ່ເທິງໃບຫນ້າ, ພວກມັນມັກຈະຖືກເອີ້ນວ່າ papules fibrous ຫຼື adenoma sebaceum; ກ່ຽວກັບອະໄວຍະວະ, ເຂົາເຈົ້າເອີ້ນວ່າ pearly penile papules ; ພາຍໃຕ້ເລັບ, ພວກມັນຖືກເອີ້ນວ່າ periungual angiofibromas ຫຼື tumors Koenen; ແລະຢູ່ໃນປາກ, ພວກມັນຖືກເອີ້ນວ່າ fibromas ປາກ. Angiofibromas ໃບຫນ້າແມ່ນລັກສະນະທີ່ໂດດເດັ່ນຂອງ tuberous sclerosis (TS) , ເປັນຄວາມຜິດປົກກະຕິທາງພັນທຸກໍາທີ່ມີຜົນຕໍ່ຜິວຫນັງ, ຫມາກໄຂ່ຫຼັງ, ຫົວໃຈ, ສະຫມອງ, ແລະປອດ. ປົກກະຕິແລ້ວພວກມັນພັດທະນາເທິງໃບໜ້າໃນຊ່ວງໄວເດັກ ຫຼືໄວໜຸ່ມໃນບຸກຄົນທີ່ມີ TS. ການມີ angiofibromas ໃບຫນ້າສາມຫຼືຫຼາຍກວ່ານັ້ນຫຼືສອງຫຼືຫຼາຍກວ່ານັ້ນ angiofibromas periungual ແມ່ນຖືວ່າມີຄວາມສໍາຄັນໃນການວິນິດໄສ TS. ນອກຈາກນັ້ນ, angiofibromas ຫຼາຍໆໃບອາດມີຢູ່ໃນສະພາບ (multiple endocrine neoplasia type 1 (MEN-1) ແລະ Birt-Hogg-Dubé syndrome) . Pearly penile papules ພົບເຫັນຢູ່ຕາມຂອບໃບຄໍ ແລະ sulcus ຂອງອະໄວຍະວະເພດ. ພວກມັນເປັນຕຸ່ມທີ່ຄົງຄ້າງ, ບໍ່ເຈັບປວດ ມັກຈະພົບເຫັນຢູ່ໃນຜູ້ຊາຍທີ່ບໍ່ໄດ້ຕັດສີດ. Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
1) ໃບຫນ້າ
Fibrous papule
2) ອະໄວຍະວະເພດ
Pearly penile papule
3) ພາຍໃຕ້ເລັບມື ຫຼືເລັບຕີນ
Periungual angiofibroma