Livedoid vasculitis
Livedoid vasculitis ເປັນພະຍາດຜິວໜັງຊໍາເຮື້ອທີ່ພົບເຫັນສ່ວນໃຫຍ່ໃນແມ່ຍິງໄວໜຸ່ມຫາໄວກາງຄົນ. ຕົວຫຍໍ້ຫນຶ່ງທີ່ໃຊ້ເພື່ອອະທິບາຍລັກສະນະຂອງມັນແມ່ນ "ບາດແຜ purpuric ເຈັບປວດທີ່ມີຮູບແບບ reticular ຂອງ extremities ຕ່ໍາ" (PURPLE). ມັນກ່ຽວຂ້ອງກັບພະຍາດຈໍານວນຫນຶ່ງ, ລວມທັງ hypertension venous ຊໍາເຮື້ອແລະ varicosities.
☆ ໃນປີ 2022 Stiftung Warentest ຜົນໄດ້ຮັບຈາກເຢຍລະມັນ, ຄວາມພໍໃຈຂອງຜູ້ບໍລິໂພກກັບ ModelDerm ແມ່ນຕໍ່າກວ່າການປຶກສາຫາລືທາງດ້ານການປິ່ນປົວທາງໂທລະສັບເລັກນ້ອຍເທົ່ານັ້ນ.
ມັນສາມາດມາພ້ອມກັບຄວາມເຈັບປວດ.
References
Livedoid vasculopathy ເປັນສະພາບຜິວໜັງທີ່ຫາຍາກ ມີລັກສະນະເປັນແຜທີ່ເຈັບປວດທີ່ຍັງຄົງຄ້າງຢູ່ຂາລຸ່ມ.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy ເປັນສະພາບຜິວໜັງທີ່ຫາຍາກທີ່ເຮັດໃຫ້ເກີດບາດແຜຢູ່ຂາລຸ່ມ, ເຊິ່ງເຮັດໃຫ້ຮອຍແປ້ວຈືດຈາງທີ່ເອີ້ນວ່າ atrophie blanche. ໃນຂະນະທີ່ສາເຫດທີ່ແນ່ນອນຍັງບໍ່ຊັດເຈນ, ມັນເຊື່ອວ່າການເພີ່ມຂື້ນຂອງເສັ້ນເລືອດ (hypercoagulability) ແມ່ນປັດໃຈຕົ້ນຕໍ, ການອັກເສບມີບົດບາດຮອງ. ປັດໃຈທີ່ເຮັດໃຫ້ເກີດການກ້າມປະກອບມີດັ່ງນີ້ - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. ໃນການກວດ biopsies, ສະພາບດັ່ງກ່າວສະແດງໃຫ້ເຫັນເຖິງການອຸດຕັນຂອງເສັ້ນເລືອດໃນເສັ້ນເລືອດ, ຄວາມຫນາແຫນ້ນຂອງຝາຂອງເຮືອ, ແລະຮອຍແປ້ວ. ການປິ່ນປົວປະກອບດ້ວຍວິທີການຫຼາຍດ້ານທີ່ເນັ້ນໃສ່ການປ້ອງກັນການອຸດຕັນຂອງເລືອດດ້ວຍຢາເຊັ່ນຢາຕ້ານເມັດເລືອດ, ເມັດເລືອດ, ແລະການປິ່ນປົວດ້ວຍ fibrinolytic. ຢາຊະນິດຕ່າງໆສາມາດນໍາໃຊ້ໄດ້ສໍາລັບສະພາບຜິວຫນັງນີ້ - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy ເປັນສະພາບທີ່ຫາຍາກທີ່ເກີດບາດແຜຢູ່ຂາທັງສອງຂ້າງ. ການສ້າງກ້ອນເລືອດໃນເສັ້ນເລືອດນ້ອຍໆແມ່ນຄິດວ່າມີສາເຫດມາຈາກການເພີ່ມຂື້ນຂອງກ້າມແລະການຫຼຸດລົງຂອງເສັ້ນເລືອດຕັນ, ພ້ອມກັບຄວາມເສຍຫາຍຂອງເສັ້ນປະສາດ. ມັນພົບເລື້ອຍໃນແມ່ຍິງ, ໂດຍສະເພາະອາຍຸລະຫວ່າງ 15 ຫາ 50 ປີ. ການເຊົາສູບຢາ, ເບິ່ງແຍງບາດແຜ, ແລະການໃຊ້ຢາເຊັ່ນ: ເມັດເລືອດ ແລະຢາຕ້ານເມັດເລືອດແມ່ນໄດ້ຜົນ.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
