Porokeratosis
☆ ໃນປີ 2022 Stiftung Warentest ຜົນໄດ້ຮັບຈາກເຢຍລະມັນ, ຄວາມພໍໃຈຂອງຜູ້ບໍລິໂພກກັບ ModelDerm ແມ່ນຕໍ່າກວ່າການປຶກສາຫາລືທາງດ້ານການປິ່ນປົວທາງໂທລະສັບເລັກນ້ອຍເທົ່ານັ້ນ.
ຂອບໃບແຂງ ເປັນລັກສະນະ.
References
Porokeratosis ເປັນສະພາບຜິວທີ່ຫາຍາກທີ່ມີລັກສະນະເປັນບັນຫາ keratinization, ເຮັດໃຫ້ເກີດການຍົກຂຶ້ນມາ, ເປັນຮູບວົງມົນ ຫຼືເປັນຕຸ່ມໆເທິງຜິວໜັງ. ລັກສະນະການກໍານົດຂອງມັນພາຍໃຕ້ກ້ອງຈຸລະທັດແມ່ນການມີ cornoid lamella, ການຈັດລຽງສະເພາະຂອງຈຸລັງຢູ່ໃນຊັ້ນເທິງຂອງຜິວຫນັງ. Porokeratosis ມາໃນຮູບແບບຕ່າງໆ (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . ມັນເປັນສິ່ງສໍາຄັນທີ່ຈະສັງເກດວ່າ porokeratosis ສາມາດພັດທະນາໄປສູ່ມະເຮັງຜິວຫນັງ. ວິທີທີ່ດີທີ່ສຸດໃນການວິນິດໄສ porokeratosis ແມ່ນຜ່ານການກວດ biopsy ຂອງຊາຍແດນທີ່ຍົກຂຶ້ນມາ, ເຖິງແມ່ນວ່າໃນປັດຈຸບັນບໍ່ມີໂປໂຕຄອນການປິ່ນປົວມາດຕະຖານ.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) ເປັນພະຍາດຂອງ keratinization ຜິດປົກກະຕິ. ມັນແມ່ນ ໜຶ່ງ ໃນຫົກຊະນິດຂອງ porokeratosis, ແລະໂດຍທົ່ວໄປແລ້ວມັນມີຜົນກະທົບຕໍ່ພື້ນທີ່ທີ່ໃຫຍ່ກວ່າເມື່ອທຽບກັບບ່ອນອື່ນ (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . ປະເພດຂອງ porokeratosis eruptive ມັກຈະເຊື່ອມຕໍ່ກັບມະເຮັງ, ພູມຕ້ານທານອ່ອນແອ, ຫຼືອັກເສບ. ປັດໃຈຄວາມສ່ຽງກ່ຽວຂ້ອງກັບພັນທຸກໍາ, ການສະກັດກັ້ນພູມຕ້ານທານ, ແລະການຖືກແດດ. DSAP ເລີ່ມຕົ້ນເປັນຕຸ່ມສີບົວ ຫຼືສີນ້ຳຕານ ທີ່ມີຂອບຍົກຂຶ້ນໃນບໍລິເວນທີ່ຖືກແສງແດດ, ບາງເທື່ອເຮັດໃຫ້ເກີດອາການຄັນເລັກນ້ອຍ. ການປິ່ນປົວແຕກຕ່າງກັນ ແລະອາດຮວມມີຄຣີມທາ, ການປິ່ນປົວດ້ວຍແສງ, ຫຼືຢາເຊັ່ນ: 5-fluorouracil ຫຼື retinoids. ບາດແຜເຫຼົ່ານີ້ຖືກພິຈາລະນາເປັນມະເຮັງກ່ອນ, ມີໂອກາດ 7. 5 - 10 % ທີ່ຈະປ່ຽນເປັນເຊລ squamous ຫຼື carcinoma cell basal.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
ຜູ້ຊາຍອາຍຸ 52 ປີ, ກ່ອນຫນ້ານີ້ມີສຸຂະພາບດີ, ມີອາການແປຮູບວົງແຫວນຢູ່ປາຍຕີນທີ່ສີ່ຂອງລາວ, ເຊິ່ງຢູ່ນັ້ນເປັນເວລາ 2 ປີ, ໂດຍບໍ່ມີອາການໃດໆ. ມັນເລີ່ມຕົ້ນເປັນກ້ອນນ້ອຍ, ແຂງແລະຂະຫຍາຍອອກໄປຂ້າງນອກໃນໄລຍະ. ເຖິງວ່າຈະມີການພະຍາຍາມການປິ່ນປົວຕ່າງໆເຊັ່ນ cryotherapy, ຄີມ, ຢາຕ້ານເຊື້ອ, ແລະຢາຕ້ານເຊື້ອ, patch ບໍ່ໄດ້ດີຂຶ້ນ. ການກວດສອບມັນຢ່າງໃກ້ຊິດກັບ dermocopsy ສະແດງໃຫ້ເຫັນຈຸດສູນກາງແຫ້ງ, ສີແດງທີ່ມີຂອບຫນາ, rough. ຊິ້ນສ່ວນນ້ອຍໆຂອງຜິວຫນັງທີ່ເອົາມາຈາກຂອບຂອງແຜ່ນແພສະແດງໃຫ້ເຫັນການຂະຫຍາຍຕົວຂອງເຊນທີ່ຜິດປົກກະຕິໃນຊັ້ນນອກຂອງຜິວຫນັງ, ຢືນຢັນການວິນິດໄສ porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
ສ່ວນຫຼາຍແລ້ວການກວດ biopsy ໄດ້ຖືກປະຕິບັດເນື່ອງຈາກວ່າມັນສາມາດມີລັກສະນະຄ້າຍຄືກັນກັບ actinic keratosis ຫຼື carcinoma ຈຸລັງ squamous.