Porokeratosis
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ໃນປີ 2022 Stiftung Warentest ຜົນໄດ້ຮັບຈາກເຢຍລະມັນ, ຄວາມພໍໃຈຂອງຜູ້ບໍລິໂພກກັບ ModelDerm ແມ່ນຕໍ່າກວ່າການປຶກສາຫາລືທາງດ້ານການປິ່ນປົວທາງໂທລະສັບເລັກນ້ອຍເທົ່ານັ້ນ.
ໃນປີ 2022 Stiftung Warentest ຜົນໄດ້ຮັບຈາກເຢຍລະມັນ, ຄວາມພໍໃຈຂອງຜູ້ບໍລິໂພກກັບ ModelDerm ແມ່ນຕໍ່າກວ່າການປຶກສາຫາລືທາງດ້ານການປິ່ນປົວທາງໂທລະສັບເລັກນ້ອຍເທົ່ານັ້ນ.
ຂອບໃບແຂງແມ່ນລັກສະນຍ.
relevance score : -100.0%
ReferencesPorokeratosis ເປັນສະພາບຜິວທີ່ຫາຍາກ ມີລັກສະນະການກະກຽມ keratinization ທີ່ເຮັດໃຫ້ເກີດການຍົກຂຶ້ນ ແລະປະກອບດ້ວຍຮູບແບບວົງມົນ ຫຼື ຕຸ່ມໆ ທີ່ຕັ້ງຢູ່ເທິງຜິວໜັງ. ລັກສະນະການກໍານົດຂອງມັນໃນຊັ້ນຕ່າງໆ ມີ cornoid lamella ທີ່ສະແດງຢູ່ພາຍໃຕ້ກ້ອງຈຸລະທັດ ແລະການຈັດລຽງຂອງຈຸລັງຢູ່ຊັ້ນເທິງຂອງຜິວຫນັງ. Porokeratosis ມີຮູບແບບຕ່າງໆ ອັດຕະໂນມັດເຊັ່ນ (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). ມັນເປັນສິ່ງສໍາຄັນທີ່ຈະສັງເກດວ່າ porokeratosis ອາດພັດທະນາເປັນມະເຮັງຜິວຫນັງ. ວິທີທີ່ດີທີ່ສຸດໃນການວິນິດໄສ porokeratosis ແມ່ນຜ່ານການກວດຊັບຊ້າງ (biopsy) ຂອງຊາຍແດນທີ່ສັງເກດ, ແມ່ນແຕ່ປັດຈຸບັນຍັງບໍ່ມີການປິ່ນປົວມາດຕະຖານ.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) ເປັນພະຍາດຂອງ keratinization ຜິດປົກກະຕິ. ມັນແມ່ນຫນຶ່ງໃນຫົກຊະນິດຂອງ porokeratosis ແລະໂດຍທົ່ວໄປມັນມີຜົນກະທົບຕໍ່ພື້ນທີ່ທີ່ກວ່າບ່ອນອື່ນ (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). ປະເພດຂອງ porokeratosis eruptive ມັກຈະເຊື່ອມຕໍ່ກັບມະເຮັງ, ພູມຕ້ານທານໂດຍຊ່ວຍອາການ, ຫຼືອັກເສບ. ການປ່ຽນແປງການສ່ຽງກ່ຽວຂ້ອງກັບພັນທຸກໍາ, ການສະກັດກັ້ນພູມຕ້ານທານ, ແລະການຖືກແດດ. DSAP ເລີ່ມຕົ້ນເປັນຕຸ່ມສີບົວ ຫຼື ສີນ້ຳຕານ ທີ່ມີຂອບຍົກຂຶ້ນໃນບໍລິເວນທີ່ເຂົາແສງແດດ, ບາງເທື່ອເຮັດໃຫ້ເກີດອາການຄັນເລັກນ້ອຍ. ການປິ່ນປົວທີ່ແຕກຕ່າງກັນ ອາດຮວມມີຄຣີມທາ, ການປິ່ນປົວດ້ວຍແສງ, ຫຼືຢາເຊັ່ນ 5-fluorouracil ຫຼື retinoids. ບາດແຜ່ນີ້ຖືກພິຈາລະນາເປັນມະເຮັງກ່ອນ, ມີໂອກາດ 7.5‑10% ທີ່ຈະປ່ຽນເປັນ squamous cell ຫຼື basal carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
ຜູ້ຊາຍ ອາຍຸ 52 ປີ, ກ່ອນຫນ້ານີ້ມີສຸຂະພາບດີ, ແຕ່ໄດ້ພົບອາການແປຮູບວົງແຫວນຢູ່ປາຍຕີນທີ່ສີ່ຂອງລາວ ຕັ້ງແຕ່ 2 ປີກ່ອນ, ບໍ່ມີອາການອື່ນໃດເພີ່ມ. ອາການເລີ່ມໂດຍການກ້ອນນ້ອຍ, ແຂງ ແລະ ຂະຫຍາຍອອກມາທາງດ້ານນອກໃນໄລຍະສັ່ງ. ພະຍາຍາມປິ່ນປົວຕ່າງໆ ເຊັ່ນ cryotherapy, ຄີມ, ຢາຕ້ານເຊື້ອ ແລະ patch ບໍ່ສຳເລັດ. ການກວດສອບດ້ວຍ dermocopsy ສະແດງຈຸດສູນກາງແຫ້ງ, ສີແດງມີຂອບຫນາ, ແລະ rough. ຊິ້ນສ່ວນນ້ອຍຂອງຜິວຫນັງທີ່ມາຈາກຂອບຂອງແຜ່ນແພສະແດງການຂະຫຍາຍຂອງເຊນທີ່ຜິດປົກກະຕິໃນຊັ້ນນອກຂອງຜິວຫນັງ, ຢືນຢັນການວິນິດໄສ porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
ສ່ວນໃຫຍ່ຂອງການກວດ biopsy ໄດ້ຖືກດໍາເນີນເພາະວ່າມັນອາດຈະມີລັກສະນະຄ້າຍກັນກັບ actinic keratosis ຫຼື squamous cell carcinoma.