Urticaria pigmentosa
Urticaria pigmentosa ແມ່ນຮູບແບບທົ່ວໄປທີ່ສຸດຂອງ mastocytosis cutaneous. ມັນເປັນພະຍາດທີ່ຫາຍາກທີ່ເກີດຈາກຈໍານວນຈຸລັງ mast ຫຼາຍເກີນໄປໃນຜິວຫນັງທີ່ເຮັດໃຫ້ເກີດອາການຄັນຫຼືບາດແຜຕາມຜິວຫນັງໃນເວລາທີ່ລະຄາຍເຄືອງ. ມັກຈະເຫັນຈຸດສີແດງ ຫຼືສີນ້ຳຕານຢູ່ຕາມຜິວໜັງ, ໂດຍທົ່ວໄປແລ້ວບໍລິເວນໜ້າເອິກ, ໜ້າຜາກ ແລະຫຼັງ. ຈຸລັງ mast ເຫຼົ່ານີ້, ເມື່ອລະຄາຍເຄືອງ (ເຊັ່ນ: ໂດຍການຖູຜິວຫນັງ, ການສໍາຜັດກັບຄວາມຮ້ອນ), ຜະລິດ histamine ຫຼາຍເກີນໄປ, ເຮັດໃຫ້ເກີດອາການແພ້ທີ່ເຮັດໃຫ້ເກີດອາການຄັນຄາຍໃນພື້ນທີ່ຂອງການລະຄາຍເຄືອງ, ບາງຄັ້ງເອີ້ນວ່າ "ອາການຂອງ Darier".
☆ ໃນປີ 2022 Stiftung Warentest ຜົນໄດ້ຮັບຈາກເຢຍລະມັນ, ຄວາມພໍໃຈຂອງຜູ້ບໍລິໂພກກັບ ModelDerm ແມ່ນຕໍ່າກວ່າການປຶກສາຫາລືທາງດ້ານການປິ່ນປົວທາງໂທລະສັບເລັກນ້ອຍເທົ່ານັ້ນ.
References
Mastocytosis ແມ່ນສະພາບທີ່ມີຈຸລັງ mast ເກີນ, ມັກຈະພົບເຫັນຢູ່ໃນພາກສ່ວນຕ່າງໆຂອງຮ່າງກາຍເຊັ່ນ: ຜິວຫນັງ, ໄຂກະດູກ, ແລະລະບົບຍ່ອຍອາຫານ. ອີງຕາມອົງການອະນາໄມໂລກ (WHO) , cutaneous mastocytosis ສາມາດແບ່ງອອກເປັນສາມປະເພດຕົ້ນຕໍ. ປະເພດທໍາອິດ (mastocytomas) ປະກອບດ້ວຍ lesions ຫຼືຈໍານວນຫນ້ອຍ (≤3) lesions. ປະເພດທີສອງ (urticaria pigmentosa) ປະກອບດ້ວຍຫຼາຍ lesions, ປົກກະຕິຕັ້ງແຕ່ຫຼາຍກ່ວາ 10 ຫາຫນ້ອຍກວ່າ 100. ປະເພດສຸດທ້າຍສະແດງໃຫ້ເຫັນການມີສ່ວນຮ່ວມຢ່າງກວ້າງຂວາງໃນທົ່ວຜິວຫນັງ. Urticaria pigmentosa ແມ່ນຮູບແບບທີ່ພົບເລື້ອຍທີ່ສຸດຂອງ mastocytosis cutaneous ໃນເດັກນ້ອຍ, ແຕ່ມັນກໍ່ສາມາດເກີດຂື້ນໃນຜູ້ໃຫຍ່. ປົກກະຕິແລ້ວມັນເປັນສະພາບທີ່ບໍ່ເປັນອັນຕະລາຍທີ່ມັກຈະປັບປຸງໃນໄລຍະໄວລຸ້ນ. ບໍ່ຄືກັບ mastocytosis ຜູ້ໃຫຍ່, urticaria pigmentosa ບໍ່ຄ່ອຍມີຜົນກະທົບຕໍ່ອະໄວຍະວະພາຍໃນ. ລັກສະນະທີ່ໂດດເດັ່ນອັນໜຶ່ງຂອງ urticaria pigmentosa ແມ່ນແນວໂນ້ມທີ່ຈະເຮັດໃຫ້ເກີດມີຈຸດໆນ້ອຍໆ, ອາການຄັນ, ສີນ້ຳຕານແດງ, ຫຼືສີນ້ຳຕານອອກເຫຼືອງ, ຫຼືເປັນບາດແຜຕາມຜິວໜັງ, ເຊິ່ງເອີ້ນກັນທົ່ວໄປວ່າເປັນລົມ. ຈຸດເຫຼົ່ານີ້ມັກຈະປະກົດຢູ່ໃນໄວເດັກ ແລະສາມາດຢູ່ຕະຫຼອດຊີວິດ.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
ເດັກນ້ອຍອາຍຸ 6 ປີຄົນໜຶ່ງ ມີອາການສີດຳຫຼາຍຈຸດ ເຊິ່ງປະກົດຂຶ້ນເທິງໜັງຫົວ ແລະ ຈາກນັ້ນແຜ່ລາມໄປທົ່ວໃບໜ້າ ແລະ ຜິວໜັງ ໃນໄລຍະ 6 ເດືອນຜ່ານມາ. ນາງໄດ້ກ່າວເຖິງຮູ້ສຶກວ່າພວກມັນລຸກຂຶ້ນ, ປ່ຽນເປັນສີແດງ, ແລະມີອາການຄັນເມື່ອມີຄວາມກົດດັນ. ນາງບໍ່ມີອາການຖອກທ້ອງ, ຮາກ, ຖອກທ້ອງ, ຫຼືຫາຍໃຈຝືດ, ແລະປະຫວັດທາງການແພດສ່ວນຕົວ ແລະຄອບຄົວຂອງນາງບໍ່ໄດ້ໃຫ້ຂໍ້ຄຶດທີ່ກ່ຽວຂ້ອງ. ຜ່ານການກວດກາ, ພວກເຮົາພົບເຫັນຈຸດດ່າງດຳຫຼາຍຈຸດຢູ່ໜັງຫົວ, ໜ້າຜາກ, ໃບໜ້າ ແລະ ຄໍ, ພ້ອມກັບມີຈຸດດ່າງດຳຂຶ້ນຢູ່ໜ້າເອິກ ແລະ ຫລັງ. ທາເບົາໆ ທາຈຸດທີ່ມີອາການບວມ ແລະຄັນພາຍໃນ 2 ນາທີ, ແຕ່ອາການຈາງລົງພາຍໃນ 15-20 ນາທີ (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
