Erythema nodosum - Mazginė Eritema
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Atrodo kaip skausmingas eriteminis mazgelis ant kojos.
References
Erythema nodosum yra labiausiai paplitęs panikulito tipas, kuriam būdingi skausmingi raudoni mazgeliai, daugiausia randami ant blauzdų. Tiksli jo priežastis lieka nežinoma, bet atrodo, kad ji atsiranda dėl perdėto atsako į įvairius veiksnius. Nors jo kilmė dažnai neaiški, prieš diagnozuojant primary erythema nodosum būtina atmesti kitas pagrindines sąlygas. Tai gali rodyti sisteminių ligų, tokių kaip infekcijos, uždegimai, vėžys ar reakcija į vaistus, atsiradimą. Įprasti paleidikliai yra strep infections, tuberculosis, sarcoidosis, Behçet's disease, inflammatory bowel disease, certain medications, and pregnancy.
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis reiškia įvairias uždegimines ligas, turinčias įtakos riebaliniam audiniui po oda. Šios sąlygos vaikams yra nedažnos. Panniculitis gali būti pagrindinė sisteminės būklės problema arba antrinė reakcija dėl tokių veiksnių kaip infekcija, sužalojimas ar tam tikri vaistai. Nepriklausomai nuo priežasties, dauguma panniculitis tipų rodo panašius simptomus, įskaitant skausmingus raudonus mazgelius po oda.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , riebalinio sluoksnio po oda uždegimas, yra reta būklė, dažniausiai pasireiškianti kaip patinę mazgeliai ar dėmės. Erythema nodosum (EN) yra labiausiai paplitęs tipas, kurį dažnai sukelia įvairūs veiksniai. Nors maždaug 55% atvejų neturi aiškios priežasties, dažniausiai sukeliančios priežastys yra infekcijos, vaistai, tam tikros ligos, tokios kaip sarkoidozė ir uždegiminė žarnyno liga, nėštumas ir vėžys. EN dažniausiai pasireiškia paaugliams ir jauniems suaugusiems, dažniau moterims. Prieš tai dažnai pasireiškia bendras ligos pojūtis, trunkantis nuo vienos iki trijų savaičių, su tokiais simptomais kaip karščiavimas ir viršutinių kvėpavimo takų problemos. Tada atsiranda raudoni mazgeliai, dažniausiai išorinėse rankų ir kojų pusėse, sukeliantys skausmą. Tiksli EN priežastis nėra visiškai suprantama, tačiau manoma, kad ji apima imuninius kompleksus mažose riebalinio sluoksnio kraujagyslėse ir sukelia uždegimą. Paprastai biopsija parodo riebalų sluoksnio uždegimą, nepažeidžiant kraujagyslių. Net ir nesant specialaus pagrindinės priežasties gydymo, EN dažnai išnyksta savaime. Taigi daugumai pacientų reikia tik palaikomosios jų simptomų priežiūros.
Panniculitis, an inflammation of the fat layer under the skin, is a rare condition usually showing up as swollen nodules or patches. Erythema nodosum (EN) is the most common type, often triggered by various factors. While around 55% of cases have no clear cause, common triggers include infections, medications, certain diseases like sarcoidosis and inflammatory bowel disease, pregnancy, and cancer. EN usually appears in teens and young adults, more often in females. It's often preceded by a general feeling of illness lasting one to three weeks, with symptoms like fever and upper respiratory issues. Then, red nodules appear, usually on the outer sides of arms and legs, causing pain. EN's exact cause isn't fully understood, but it's believed to involve immune complexes in small blood vessels of the fat layer, leading to inflammation. Typically, a biopsy shows inflammation in the fat layer without damage to blood vessels. Even without specific treatment for the underlying cause, EN often resolves on its own. So, most patients need only supportive care for their symptoms.
Panniculitis, an inflammation of the fat layer under the skin, is a rare condition usually showing up as swollen nodules or patches. Erythema nodosum (EN) is the most common type, often triggered by various factors. While around 55% of cases have no clear cause, common triggers include infections, medications, certain diseases like sarcoidosis and inflammatory bowel disease, pregnancy, and cancer. EN usually appears in teens and young adults, more often in females. It's often preceded by a general feeling of illness lasting one to three weeks, with symptoms like fever and upper respiratory issues. Then, red nodules appear, usually on the outer sides of arms and legs, causing pain. EN's exact cause isn't fully understood, but it's believed to involve immune complexes in small blood vessels of the fat layer, leading to inflammation. Typically, a biopsy shows inflammation in the fat layer without damage to blood vessels. Even without specific treatment for the underlying cause, EN often resolves on its own. So, most patients need only supportive care for their symptoms.
Mazginė eritema diagnozuojama kliniškai. Norint patvirtinti neaiškią diagnozę, galima paimti biopsiją ir ištirti mikroskopu. Norint išvengti plaučių ligų, ypač sarkoidozės ir tuberkuliozės, reikia atlikti krūtinės ląstos rentgenogramą.