Syphilis - Sifilis
☆ 2022 m. Stiftung Warentest iš Vokietijos rezultatai rodo, kad vartotojų pasitenkinimas ModelDerm buvo tik šiek tiek mažesnis nei mokamų nuotolinės medicinos konsultacijų.
Chancres ― pirminė sifilinė infekcija, kurią sukėlė Treponema pallidum
References
Sifilis yra lytiniu keliu plintanti liga, kurią sukelia bakterija Treponema pallidum. Šiame tyrime daugiausia dėmesio skiriame 57 18–68 metų pacientams, sergantiems antriniu sifiliu.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Sifilis yra bakterinė infekcija, kurią sukelia Treponema pallidum. Jis gali imituoti įvairias ligas, todėl gauna slapyvardį great imitator. Sifiliu vis dar serga milijonai žmonių visame pasaulyje, tačiau jį galima veiksmingai gydyti penicilinu.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum sukelia sifilį per lytinius santykius arba motinos kūdikiui nėštumo metu. Nors yra paprastų testų diagnozei nustatyti, o gydymas vienu ilgai veikiančiu penicilino šūviu veikia gerai, sifilis vėl tampa didele problema visame pasaulyje. Tai ypač pasakytina apie vyrus, turinčius lytinių santykių su vyrais (MSM) šalyse, kuriose yra didelės ir vidutinės pajamos. Nors kai kurios mažas pajamas gaunančios šalys įvykdė PSO tikslus sustabdyti sifilio perdavimą iš motinos kūdikiui, nerimą keliantis sifilio augimas tarp ŽIV užsikrėtusių MSM.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Padidėjusios kepenys: tai dažnai randama ir gali atsitikti kartu su padidėjusia blužniu. Kepenų biopsijos tyrimas tamsaus lauko mikroskopu gali atskleisti spirochetą. Kepenų funkcijos tyrimai gali rodyti nukrypimus nuo normos. (2) Odos pageltimas (gelta) : ar kam nors pasireikš gelta, priklauso nuo to, kiek pažeistos kepenys. (3) Sloga: dažnai vienas iš pirmųjų požymių, dažniausiai per pirmąją savaitę po gimimo. (4) Pabrinkę limfmazgiai: taip pat dažnas bendras limfmazgių patinimas, dažniausiai neskausmingas. (5) Odos išbėrimas: bėrimas paprastai atsiranda praėjus vienai ar dviem savaitėms po slogos. Ant nugaros, sėdmenų, šlaunų ir pėdų padų galite matyti mažas raudonas arba rausvas dėmeles. Šis bėrimas gali išsivystyti į lupimąsi ir pluta.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnostika ir gydymas
VDRL ir RPR gali būti naudojami neseniai užsikrėtimui patvirtinti ir sifilio patikrinimui. FTA-ABS testas yra konkretesnis testas ir gali būti naudojamas patikrinti ankstesnės infekcijos istoriją. Penicilinas vartojamas sifiliui gydyti.