Amyloidosis - Amiloidoze
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2022. gada Stiftung Warentest rezultātos no Vācijas patērētāju apmierinātība ar ModelDerm bija tikai nedaudz zemāka nekā ar maksas telemedicīnas konsultācijām.
2022. gada Stiftung Warentest rezultātos no Vācijas patērētāju apmierinātība ar ModelDerm bija tikai nedaudz zemāka nekā ar maksas telemedicīnas konsultācijām.
Klasiskā amiloidoze (Amyloidosis) – sejas vaibsti
relevance score : -100.0%
References26‑gadu veca sieviete ieradās mūsu klīnikā, sūdzoties par niezošiem izsitumiem uz kājām, kas bija jau 10 gadu garumā. Neskatoties uz steroīdu un tazarotēna krēmu lietošanu, izsitumi neuzlabojās. Viņai nebija atbilstošas ģimenes vēstures. Kad viņu izmeklējām, atradām paceltus, raupjus plankumus viņas kāju priekšpusē, kas atbilst slimībai, ko sauc par lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis ir reta ādas slimība, kas saistīta ar nepārejošu, nezināma iemesla niezi. Tā parasti izpaužas kā pacelti, mainīgas krāsas plankumu kopumi uz ādas virsējām virsmām. Lichen Amyloidosis biežāk sastopama cilvēkiem vecumā no 50 līdz 60 gadiem, un diemžēl to nevar izārstēt. Pašlaik pieejamās ārstēšanas metodes bieži nedarbojas pietiekami labi.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis ir ilgstoša, niezoša ādas slimība. Tā ir pazīstama ar sabiezinātām izciļņu kopām, kas galvenokārt atrodas uz muguras, apakšstilbiem, augšstilbiem un rokām. Mikroskopiskā izmeklēšanā Lichen amyloidosis izpaužas ar amiloīda uzkrāšanos ādas augšējā slānī, kā arī ārējā ādas slāņa sabiezēšanu un paplašināšanos. Lai gan precīzs Lichen amyloidosis cēlonis vēl nav pilnībā izprasts, iepriekšējie pētījumi ir saistījuši to ar tādiem faktoriem kā ādas berze, šūnu nāve, vīrusu infekcijas un citi faktori. Šķiet, ka Lichen amyloidosis ir saistīts ar vairākiem citiem ādas stāvokļiem, piemēram, atopic dermatitis, lichen planus un mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnostika un ārstēšana
#Electrophoresis of blood or urine
#Skin biopsy