Herpes simplex
☆ 2022. gada Stiftung Warentest rezultātos no Vācijas patērētāju apmierinātība ar ModelDerm bija tikai nedaudz zemāka nekā ar maksas telemedicīnas konsultācijām.
Herpes simplex uz lūpas.
Herpes simplex ― Herpes simplex infekcija pirkstos ir biežāk sastopama maziem bērniem nekā pieaugušajiem.
References
HSV-1 infekcija progresē ar primāru epitēlija šūnu infekciju, kam seko latentums, galvenokārt neironos, un reaktivācija. HSV-1 parasti izraisa sākotnējos un atkārtotus vezikulāros izvirdumus, galvenokārt uz mutes un dzimumorgānu gļotādām. Tās izpausmes svārstās no orolabiāla herpes līdz dažādiem stāvokļiem, piemēram, herpetisks folikulīts, ādas infekcijas, acu bojājumi un smagi gadījumi, piemēram, herpes encefalīts. Pretvīrusu terapija palīdz pārvaldīt HSV infekciju.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 2 (HSV-2) ir plaši izplatīta infekcija, kas skar aptuveni 22% pieaugušo vecumā no 12 gadiem, kopā 45 miljonus pieaugušo Amerikas Savienotajās Valstīs. Lai gan HSV-1 parasti izraisa čūlas mutē, tas var izraisīt arī dzimumorgānu bojājumus. Tomēr, ja pacientiem ir dzimumorgānu bojājumi, HSV-2 parasti ir galvenā problēma. HSV-2 uzliesmojumu simptomi bieži ir neskaidri, piemēram, dzimumorgānu nieze un kairinājums, kas var aizkavēt diagnostiku un ārstēšanu. Šī kavēšanās var izraisīt turpmāku pārnešanu uz neinficētām personām.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus (HSV) pusaudžiem un pieaugušajiem bieži izraisa tādas infekcijas kā dzimumorgānu herpes un aukstumpumpas. Ja HSV inficē zīdaini pirmajās 4–6 dzīves nedēļās, tas var izraisīt smagu slimību ar nopietnām sekām. Ātri diagnosticēt jaundzimušo HSV infekciju ir ļoti svarīgi, lai apturētu slimības pasliktināšanos, novēršot neiroloģiskas problēmas (pat nāvi) .
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex infekcija ir ļoti izplatīta, un grūtnieces to var pārnest uz mazuļiem. Šis vīruss jaundzimušajiem var izraisīt nopietnas veselības problēmas vai pat nāvi. Lai gan grūtniecības laikā tas ir reti, tas bieži notiek dzemdību laikā. Risks ir visaugstākais, ja māte inficējas vēlākās grūtniecības stadijās. Tomēr šo risku var samazināt, izmantojot pretvīrusu zāles vai noteiktās situācijās izvēloties C sekciju.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Herpes simplex virus (HSV) 1. Un 2. Tips inficē daudzus cilvēkus visā pasaulē. Parasti vīruss pēc ādas inficēšanas nervu šūnās paliek kluss, taču vēlāk tas var atkal aktivizēties, izraisot aukstumpumpas. Dažreiz tas izraisa nopietnas problēmas, piemēram, acu infekcijas, smadzeņu iekaisumu vai bīstamus apstākļus jaundzimušajiem un cilvēkiem ar vāju imūnsistēmu. Lai gan pašreizējās zāles palīdz kontrolēt infekcijas, joprojām ir bažas par zāļu rezistences un blakusparādību risku. Mums ir vajadzīgas jaunas zāles, lai labāk mērķētu pret vīrusu.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Ir divu veidu herpes simplex vīruss, 1. tips (HSV-1) un 2. tips (HSV-2). HSV-1 biežāk izraisa infekcijas ap muti, savukārt HSV-2 biežāk izraisa dzimumorgānu infekcijas. Tos pārnēsā tiešā saskarē ar inficēto personu. Dzimumorgānu herpes tiek klasificēts kā seksuāli transmisīvās infekcijas. Tas var tikt izplatīts zīdainim dzemdību laikā. Pēc inficēšanās vīrusi tiek transportēti pa maņu nerviem uz nervu šūnu ķermeņiem, kur tie atrodas visu mūžu. Atkārtošanās cēloņi var būt: pavājināta imūnsistēma, stress un saules gaismas iedarbība.
Vairumā gadījumu pretvīrusu zāles lieto tikai tad, ja simptomi ir smagi. Ikdienas pretvīrusu zāles var parakstīt kādam, kam ir ļoti bieži infekcija. Vakcīna nav pieejama, un vakcinācija pret jostas rozi nenovērš herpes simplex. Ārstēšana ar pretvīrusu zālēm, piemēram, acikloviru vai valacikloviru, var mazināt simptomu smagumu.
Visā pasaulē HSV-1 vai HSV-2 sastopamība pieaugušajiem ir no 60% līdz 95%. Ar HSV-1 parasti inficējas bērnībā. Aptuveni 536 miljoni cilvēku visā pasaulē (16% iedzīvotāju) 2003. gadā bija inficēti ar HSV-2, un tas ir lielāks sieviešu un jaunattīstības valstu vidū. Lielākā daļa cilvēku ar HSV-2 neapzinās, ka ir inficēti.
○ Ārstēšana — ārpusbiržas zāles
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