Prurigo nodularis
☆ 2022. gada Stiftung Warentest rezultātos no Vācijas patērētāju apmierinātība ar ModelDerm bija tikai nedaudz zemāka nekā ar maksas telemedicīnas konsultācijām.
References
Prurigo nodularis ir ilgstoša ādas slimība, kurai raksturīgi vairāki stingri izciļņi un mezgliņi, kas parasti atrodas uz roku un kāju ārējām daļām. Šo izciļņu krāsa var atšķirties no miesas toņa līdz rozā, un tie ir intensīvi niezoši. Tās var skart jebkura vecuma cilvēkus un bieži vien ir saistītas ar citām ādas slimībām, kas izraisa hronisku niezi, piemēram, atopisko dermatītu. Ārstēšanas iespējas ietver spēcīgas zāles pret niezi, zāles, kas ietekmē imūnsistēmu, un zāles, kas vērstas uz nervu sistēmu. Prurigo nodularis ārstēšana parasti ietver ilgstošu terapiju.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Ārstēšana parasti ietver krēmu vai steroīdu injekciju lietošanu skartajā zonā. Smagākos vai spītīgākos gadījumos var būt nepieciešama ārstēšana, piemēram, gaismas terapija vai zāles, kas nomāc imūnsistēmu. Talidomīds un lenalidomīds ir iespējas smagos gadījumos, taču tiem var būt nopietnas blakusparādības. Jaunākas ārstēšanas metodes (opioid receptor antagonists, neurokinin-1 receptor antagonists) ir daudzsološas, ārstējot prurigo nodularis ar mazākām blakusparādībām, salīdzinot ar talidomīdu vai lenalidomīdu.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo ir ādas slimība, kurai raksturīgs ilgstošs nieze (ilgst vairāk nekā 6 nedēļas) , ar skrāpējumiem saistīti ādas bojājumi un bieža skrāpēšana anamnēzē. Tas ietver neiroiekaisumu un fibrozi ādā.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis ir ilgstoša ādas problēma, ko raksturo niezoši mezgliņi. Mēs precīzi nezinām, kas to izraisa, bet šķiet, ka imūnsistēmas un nervu problēmām ir nozīme niezes-skrāpējumu ciklā. Pašlaik nav nevienas ASV FDA apstiprinātas ārstēšanas metodes, kas īpaši paredzētas prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Ārstēšana — ārpusbiržas zāles
Bojājuma vietas mazgāšana ar ziepēm vispār nepalīdz un var to pasliktināt. Ārpusbiržas steroīdu ziedes var palīdzēt atvieglot simptomus, taču parasti tās jālieto vairākas nedēļas, lai tās uzlabotu. Arī antihistamīna līdzekļu lietošanas turpināšana palīdz mazināt niezi.
#OTC steroid ointment
#OTC antihistamine
○ Ārstēšana
#Intralesional triamcinolone injection