Syphilis - Sifiliss
☆ 2022. gada Stiftung Warentest rezultātos no Vācijas patērētāju apmierinātība ar ModelDerm bija tikai nedaudz zemāka nekā ar maksas telemedicīnas konsultācijām.
Chancres ― primārā sifilīta infekcija ar Treponema pallidum
References
Sifiliss ir seksuāli transmisīva slimība, ko izraisa baktērija Treponema pallidum. Šajā pētījumā mēs koncentrējamies uz 57 pacientiem vecumā no 18 līdz 68 gadiem ar sekundāro sifilisu.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Sifiliss ir bakteriāla infekcija, ko izraisa Treponema pallidum. Tas var atdarināt dažādas slimības, iegūstot segvārdu great imitator. Sifiliss joprojām skar miljoniem cilvēku visā pasaulē, taču to var efektīvi ārstēt ar penicilīnu.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum izraisa sifilisu seksuāla kontakta ceļā vai no mātes bērnam grūtniecības laikā. Lai gan ir vienkārši testi, lai to diagnosticētu un ārstēšana ar vienu ilgstošas darbības penicilīna injekciju darbojas labi, sifiliss atkal kļūst par lielu problēmu visā pasaulē. Tas jo īpaši attiecas uz vīriešiem, kuriem ir sekss ar vīriešiem (MSM) valstīs ar augstiem un vidējiem ienākumiem. Lai gan dažas valstis ar zemiem ienākumiem ir sasniegušas PVO mērķus, lai apturētu sifilisa pārnešanu no mātes bērnam, HIV pozitīvo MSM vidū ir satraucošs sifilisa pieaugums.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Palielinātas aknas: tas bieži tiek konstatēts un var notikt kopā ar palielinātu liesu. Pārbaudot aknu biopsiju tumšā lauka mikroskopijā, var atklāt spirohetas klātbūtni. Aknu darbības testi var uzrādīt novirzes no normas. (2) Ādas dzeltēšana (dzelte) : tas, vai kādam parādās dzelte, ir atkarīgs no tā, cik daudz ir ietekmētas aknas. (3) Iesnas: bieži viena no pirmajām pazīmēm, parasti pirmajā nedēļā pēc dzimšanas. (4) Pietūkuši limfmezgli: bieži sastopams arī ģeneralizēts limfmezglu pietūkums, parasti nesāpīgs. (5) Izsitumi uz ādas: izsitumi parasti parādās vienu līdz divas nedēļas pēc iesnām. Jūs varat redzēt mazus sarkanus vai rozā plankumus uz muguras, sēžamvietas, augšstilbiem un pēdu zolēm. Šie izsitumi var progresēt līdz lobīšanās un garozas veidošanās.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnostika un ārstēšana
VDRL un RPR var izmantot, lai apstiprinātu neseno infekciju un pārbaudītu sifilisu. FTA-ABS tests ir specifiskāks tests, un to var izmantot, lai pārbaudītu iepriekšējo infekcijas vēsturi. Penicilīnu lieto sifilisa ārstēšanai.