Urticaria pigmentosa - Pigmenta Nātrene
Pigmenta Nātrene (Urticaria pigmentosa) ir visizplatītākā ādas mastocitozes forma. Tā ir reta slimība, ko izraisa pārmērīgs tuklo šūnu skaits ādā, kas kairinājuma gadījumā rada nātreni vai ādas bojājumus. Sarkani vai brūni plankumi bieži ir redzami uz ādas, parasti ap krūtīm, pieri un muguru. Šīs tuklās šūnas, ja tās tiek kairinātas (piemēram, berzējot ādu, iedarbojoties uz karstumu), ražo pārāk daudz histamīna, izraisot alerģisku reakciju, kas izraisa nātreni, kas lokalizēta kairinājuma zonā, ko dažreiz dēvē par "Darjē zīmi".
☆ 2022. gada Stiftung Warentest rezultātos no Vācijas patērētāju apmierinātība ar ModelDerm bija tikai nedaudz zemāka nekā ar maksas telemedicīnas konsultācijām.
References
Mastocytosis ir stāvoklis, kad ir pārāk daudz tuklo šūnu, kas bieži atrodamas dažādās ķermeņa daļās, piemēram, ādā, kaulu smadzenēs un gremošanas sistēmā. Saskaņā ar Pasaules Veselības organizācijas (PVO) datiem cutaneous mastocytosis var iedalīt trīs galvenajos veidos. Pirmais veids (mastocytomas) sastāv no atsevišķiem vai dažiem (≤3) bojājumiem. Otrais veids (urticaria pigmentosa) ietver vairākus bojājumus, parasti no vairāk nekā 10 līdz mazāk nekā 100. Pēdējais veids liecina par plaši izplatītu iesaistīšanos visā ādā. Urticaria pigmentosa ir visizplatītākā ādas mastocitozes forma bērniem, taču tā var rasties arī pieaugušajiem. Parasti tas ir nekaitīgs stāvoklis, kas bieži uzlabojas pusaudža gados. Atšķirībā no pieaugušo mastocitozes, urticaria pigmentosa reti ietekmē iekšējos orgānus. Viena no urticaria pigmentosa atšķirīgām iezīmēm ir tā tendence uz ādas radīt mazus, niezošus, sarkanbrūnus vai dzeltenbrūnus plankumus vai bojājumus, ko parasti sauc par nātreni. Šie plankumi parasti parādās bērnībā un var saglabāties visu mūžu.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
6 gadus veca meitene ieradās ar vairākiem tumšas krāsas plankumiem, kas vispirms parādījās viņas galvas ādā un pēc tam izplatījās uz viņas sejas un ķermeņa pēdējo sešu mēnešu laikā. Viņa minēja, ka jūt, ka tie paceļas, kļūst sarkani un niez, kad tika izdarīts spiediens. Viņai nebija pietvīkuma, vemšanas, caurejas vai sēkšanas, un viņas personīgā un ģimenes slimības vēsture nesniedza atbilstošus norādījumus. Pārbaudot, mēs atklājām vairākus tumšus plankumus uz viņas galvas ādas, pieres, sejas un kakla, kā arī nedaudz paceltus tumšus plankumus uz krūtīm un muguras. Viegli berzējot plankumus, 2 minūšu laikā tie uzbriest un niezoši, bet simptomi izzuda 15–20 minūšu laikā (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
