Acute generalized exanthematous pustulosis
Ny Acute generalized exanthematous pustulosis (AGEP) dia fanehoan-kevitra tsy fahita firy amin'ny hoditra izay amin'ny 90% amin'ny tranga dia mifandray amin'ny fitantanana fanafody. Ny acute generalized exanthematous pustulosis dia miavaka amin'ny fipoahan'ny hoditra tampoka izay miseho eo ho eo dimy andro aorian'ny nanombohana fanafody. Ireo fipoahana ireo dia pustules, izany hoe fipoahana kely mena fotsy na mena amin'ny hoditra izay misy akora manjavozavo na purulent (pus). Ny fery amin'ny hoditra matetika dia mivaha ao anatin'ny 1-3 andro aorian'ny fampitsaharana ny fanafody manafintohina.
☆ Tamin'ny valin'ny Stiftung Warentest 2022 avy any Alemaina, ny fahafaham-pon'ny mpanjifa amin'ny ModelDerm dia ambany kely noho ny fifampidinihana telemedicine karama.
Mipoitra tampoka ny fery miparitaka miaraka amin'ny erythema sy pustules.
References
Acute generalized exanthematous pustulosis (AGEP) dia fihetsehana amin'ny hoditra voamariky ny fivontosana kely feno pus eo amin'ny fototry ny hoditra mena. Matetika no mitranga izany rehefa misy olona mihinana fanafody sasany, toy ny antibiotika, ary miparitaka haingana manerana ny vatana. Aorian'ny fampitsaharana ny fanafody miteraka, matetika dia miala ao anatin'ny tapa-bolana ny soritr'aretina, ary matetika mamela hoditra. Na dia matetika tsy matotra sy voafetra amin'ny hoditra aza, ny tranga henjana dia azo faritana miaraka amin'ny fihetseham-po lehibe hafa toy ny Stevens-Johnson syndrome na toxic epidermal necrolysis. Ny fitsaboana dia fanohanana voalohany indrindra, ary ny prognosis amin'ny famahana tanteraka ny aretina dia matetika tsara.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Lehilahy iray 76 taona no tonga teny amin’ny sampana vonjy taitra satria niova ny hodiny tao anatin’ny roa andro. Nahita tasy mena ny dokotera ary nisy faritra natsangana teo amin'ny vatany sy ny tanany ary ny tongony. Rehefa nandeha ny fotoana, dia nitambatra ireo paty ireo, ary nipoitra toy ny mony ny faritra mena. Hita tamin'ny fitsapana ny isan'ny sela fotsy be dia be misy karazana antsoina hoe neutrophils, ary nitombo C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
