Drug eruption
☆ Tamin'ny valin'ny Stiftung Warentest 2022 avy any Alemaina, ny fahafaham-pon'ny mpanjifa amin'ny ModelDerm dia ambany kely noho ny fifampidinihana telemedicine karama.
Drug eruption dia misy fiantraikany amin'ny vatana manontolo.
References
Mety ho mafy indraindray ny fihetsiky ny hoditra vokatry ny fanafody, fantatra amin'ny hoe fipoahan'ny zava-mahadomelina. Ireo fanehoan-kevitra mahery vaika ireo, antsoina hoe severe cutaneous adverse drug reactions (SCARs) , dia heverina ho mampidi-doza. Anisan'izany ny fepetra toy ny Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Na dia tsy fahita firy aza ny SCARs , manodidina ny 2% amin'ny marary tsaboina any amin'ny hopitaly no mahatsapa izany.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Vehivavy 31 taona no nitsidika ny sampana dermatôlôjia ary nisy paty mena tsy misy fanaintainana teo an-tampon-tongony havanana. Nihinana doxycycline (100 mg) iray izy ny andro talohan'izay, taorian'ny fitsaboana tamin'ny laser picosecond ho an'ny hoditry ny mony. Tamin'ny taon-dasa, niaina olana mitovy amin'izany izy teo amin'ny toerana iray ihany rehefa avy naka doxycycline post-laser doxycycline. Tsy manana tantara ara-pitsaboana manan-danja izy ary tsy misy soritr'aretina hafa, toy ny tazo, eo an-toerana na manerana ny vatany.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) sy toxic epidermal necrolysis (TEN) dia endrika roa amin'ny fihenjanana mafy amin'ny hoditra, tsy mitovy amin'ny toetry ny hoditra hafa toy ny erythema multiforme major sy staphylococcal scalded skin syndrome, ary koa ny fihetsiky ny zava-mahadomelina. SJS/TEN dia fanehoan-kevitra tsy fahita firy sy mahery vaika miteraka fahasimban'ny hoditra sy ny mucous membrane, matetika miaraka amin'ny soritr'aretina. Amin'ny 80% amin'ny tranga, ny fanafody no antony.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Ny fipoahan'ny zava-mahadomelina dia fantatra indrindra amin'ny tantara ara-pitsaboana sy ny fizahana klinika. Ny biopsy hoditra, ny fitsirihana ra na ny fitsirihana immunologique dia mety ilaina ihany koa.
Ohatra amin'ny fanafody mahazatra mahatonga ny fipoahana dia antibiotika sy fanafody antimikrobia hafa, fanafody sulfa, fanafody manohitra ny inflammatoire tsy misy steroid (NSAIDs), fanafody simika ho an'ny homamiadana, anticonvulsant ary fanafody psychotropic.
○ Diagnose sy Fitsaboana
Raha voan'ny tazo ianao (mitombo ny hafanan'ny vatana), dia tokony hitady fitsaboana haingana araka izay azo atao ianao. Ny fanafody ahiahiana dia tokony hajanona (ohatra antibiotika, fanafody tsy misy steroidal anti-inflammatory). Alohan'ny hitsidihana ny hopitaly, ny antihistamine am-bava toy ny cetirizine na loratadine dia mety hanampy amin'ny mangidihidy sy maimaika.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Fitsapana ra (CBC, LFT, isa eosinophil)
Steroid am-bava sy antihistamines miaraka amin'ny taratasin'ny dokotera