Livedoid vasculitis
Livedoid vasculitis dia aretin'ny hoditra mitaiza hita matetika amin'ny vehivavy tanora ka hatramin'ny efa antitra. Ny fanafohezan-teny iray ampiasaina hamaritana ny endri-javatra misy azy dia ny "Fery purpuric manaintaina miaraka amin'ny endrika reticular amin'ny tendrony ambany" (PURPLE). Izy io dia mifandray amin'ny aretina maro, anisan'izany ny fiakaran'ny tosidrà venous mitaiza sy ny varicosity.
☆ Tamin'ny valin'ny Stiftung Warentest 2022 avy any Alemaina, ny fahafaham-pon'ny mpanjifa amin'ny ModelDerm dia ambany kely noho ny fifampidinihana telemedicine karama.
fanaintainany dia azo arahana.
References
Livedoid vasculopathy dia toetry ny hoditra tsy fahita firy izay misy fery maharary izay miverina hatrany amin'ny tongotra ambany.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy dia toetry ny hoditra tsy fahita firy izay miteraka fery miverimberina eo amin'ny tongotra ambany, ka mamela takaitra hatsatra antsoina hoe atrophie blanche. Na dia mbola tsy fantatra mazava aza ny tena antony, dia inoana fa ny fitomboan'ny fandatsahan-drà (hypercoagulability) no tena anton-javatra, miaraka amin'ny fivontosana mitana anjara toerana faharoa. Ny antony mahatonga ny fandatsahan-drà dia ahitana ireto manaraka ireto - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Ao amin'ny biopsy, ny toe-javatra dia mampiseho ny fivontosana ra ao anaty sambo, ny hatevin'ny rindrin'ny sambo, ary ny ratra. Ny fitsaboana dia misy fomba fiasa marobe mifantoka amin'ny fisorohana ny fikorontanan'ny ra miaraka amin'ny fanafody toy ny fanafody manohitra ny platelet, ny fanalefahana ny rà, ary ny fitsaboana fibrinolytika. Ny fanafody isan-karazany dia azo ampiasaina amin'ity aretina hoditra ity - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy dia toe-javatra tsy fahita firy ahitana fery amin'ny tongotra roa. Ny fiforonan'ny rà mandriaka ao amin'ny lalan-dra madinika dia heverina fa vokatry ny fitomboan'ny fivontosana sy ny fihenan'ny fahapotehan'ny clot, miaraka amin'ny fahasimbana eo amin'ny fonon'ny sambo. Matetika kokoa amin'ny vehivavy izany, indrindra eo anelanelan'ny 15 sy 50 taona. Nandaitra ny fialana amin'ny sigara, ny fikarakarana ratra, ary ny fampiasana fanafody toy ny fanalana rà sy ny fanafody antiplatelet.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
