Porokeratosis
☆ Tamin'ny valin'ny Stiftung Warentest 2022 avy any Alemaina, ny fahafaham-pon'ny mpanjifa amin'ny ModelDerm dia ambany kely noho ny fifampidinihana telemedicine karama.
Ny sisiny mafy mipoitra dia toetra.
References
Porokeratosis dia toe-javatra tsy fahita firy amin'ny hoditra misy olana amin'ny keratinization, ka miteraka tasy miendrika peratra na fivontosan'ny hoditra. Ny mampiavaka azy eo ambanin'ny mikraoskaopy dia ny fisian'ny cornoid lamella, firindrana manokana amin'ny sela ao amin'ny sosona ambony amin'ny hoditra. Porokeratosis dia tonga amin'ny endrika isan-karazany (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Zava-dehibe ny manamarika fa ny porokeratosis dia mety hivoatra ho homamiadan'ny hoditra. Ny fomba tsara indrindra hamantarana ny porokeratosis dia amin'ny alalan'ny biopsy amin'ny sisintany miakatra, na dia tsy misy protocole fitsaboana mahazatra amin'izao fotoana izao aza.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) dia aretin'ny keratinization tsy voafehy. Iray amin'ireo karazana porokeratosis enina izy io, ary matetika dia misy fiantraikany amin'ny faritra lehibe kokoa raha oharina amin'ny hafa (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Ny karazana porokeratose mipoitra matetika dia mifandray amin'ny homamiadana, ny hery fiarovana malemy, na ny areti-maso. Ny anton'ny risika dia ny fototarazo, ny fanafoanana ny hery fiarovana ary ny fiposahan'ny masoandro. Ny DSAP dia manomboka amin'ny fivontosana mavokely na volontsôkôlà miaraka amin'ny sisiny ambony amin'ny faritra taratra masoandro, indraindray miteraka mangidihidy kely. Ny fitsaboana dia miovaova ary mety ahitana crème topical, fitsaboana maivana, na fanafody toy ny 5-fluorouracil na retinoids. Ireo ratra ireo dia heverina ho precancerous, miaraka amin'ny 7. 5 - 10 % mety hivadika ho sela squamous na kanseran'ny sela basal.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Lehilahy iray 52 taona, salama tsara teo aloha, no niditra niaraka tamin’ny tapa-kazo fisaka miendrika peratra teo amin’ny faran’ny rantsan-tongony fahefatra, izay efa tao nandritra ny 2 taona nefa tsy nisy soritr’aretina. Niantomboka tamin'ny bozaka kely sy mafy ary nitombo hatrany ivelany rehefa nandeha ny fotoana. Na dia teo aza ny fanandramana fitsaboana isan-karazany toy ny cryotherapy, crème, antifungal ary antibiotika, dia tsy nihatsara ilay patch. Ny fandinihana azy akaiky tamin'ny dermocopsy dia nahitana foibe maina sy mena misy sisin-tany matevina sy manjavozavo. Ny hoditra kely nalaina teo amin'ny sisin'ny paty dia nampiseho fitomboan'ny sela tsy ara-dalàna teo amin'ny sosona ivelany amin'ny hoditra, nanamarina ny fisian'ny porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Matetika ny biopsy dia atao satria mety mitovitovy amin'ny keratosis actinic na kanseran'ny sela squamous.