Porokeratosishttps://en.wikipedia.org/wiki/Porokeratosis
Ko te Porokeratosis he mate onge o te keratinization. Ko te porokeratosis he mate kiri ka timata mai i te iti, he papura parauri ka tere te rahi ki te hanga i nga reinga kopikopiko, annular, hyperkeratotic, rite ki te kiritona ranei.

I te nuinga o te wa ka mahia he koiora no te mea he rite te ahua ki te keratosis actinic, ki te mate pukupuku o te puiao.

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  • Ko nga tapa maro e puta ana he ahuatanga.
    References Porokeratosis 30335323 
    NIH
    Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
     Disseminated Superficial Actinic Porokeratosis 29083728 
    NIH
    Ko te Disseminated superficial actinic porokeratosis (DSAP) he mate o te keratinization. Koia tetahi o nga momo porokeratosis e ono, a ka pa te nuinga ki nga waahi nui ka whakatauritea ki era atu (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Ko te momo pahū o te porokeratosis e hono ana ki te mate pukupuku, te ngoikore o te mate, te mumura ranei. Ko nga ahuatanga morearea ko te ira, te aukati aukati, me te ra ka kitea. Ka timata te DSAP he putunga mawhero, parauri ranei me nga taha kua ara ake ki nga waahi e kitea ana e te ra, i etahi wa ka paku te kiri. He rereke nga maimoatanga, ka uru pea ki nga aihikirīmi, te whakamaarama marama, me nga rongoa penei i te 5-fluorouracil me te retinoids. Ko enei patunga ka kiia he mate pukupuku, me te 7. 5 - 10 % te tupono ka huri ki roto i te squamous cell or basal cell carcinoma.
    Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
     Porokeratosis of Mibelli - Case reports 33150040 
    NIH
    He tangata 52-tau te pakeke, he tangata ora i mua, i tae mai me te papapa, te ahua mowhiti ki te pito o tona matimati tuawha, kua 2 tau e noho ana ki reira kaore he tohu. I timata mai he putunga iti, uaua, ka tipu ki waho i te wa. Ahakoa te whakamatau i nga momo maimoatanga penei i te cryotherapy, kirīmi, antifungal, me te patu paturopi, kaore i pai ake te papaki. I te ata tirotirohia me te dermocopsy ka kitea he pokapū maroke, whero me te taitapa matotoru, taratara. Ko tetahi wahi kiri iti i tangohia mai i te tapa o te papaki i whakaatu i te tipu rerekee o nga pūtau i te paparanga o waho o te kiri, e whakau ana i te tātaritanga o te porokeratosis of Mibelli.
    A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.