Prurigo nodularis
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References
Ko te Prurigo nodularis he mate kiri roa e tohuhia ana e te maha o nga puku me nga nodule, ka kitea ki waho o nga ringaringa me nga waewae. He rereke te tae o enei puku mai i te kiko-kiko ki te mawhero me te tino kikorangi. Ka pa ki nga tangata ahakoa te pakeke, a he maha nga wa e hono ana ki etahi atu momo kiri e mate ai te mate kiri, penei i te dermatitis atopic. Ko nga whiringa maimoatanga ko nga rongoa aukati kaha, nga raau taero e pa ana ki te punaha mate, me nga rongoa e aro ana ki te punaha nerve. Ko te whakahaere i te prurigo nodularis ko te nuinga o te waa he rongoa mo te wa roa.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
I te nuinga o te wa ko te maimoatanga ko te whakamahi kirīmi, werohanga steroids ranei ki te waahi kua pa. I roto i nga keehi tino kino, pakeke ranei, ka hiahiatia nga maimoatanga penei i te whakamaarama marama me nga rongoa ka pehia te punaha mate. Ko te Thalidomide me te lenalidomide nga whiringa mo nga keehi kino, engari ka pa mai pea nga paanga kino. Ko nga maimoatanga hou ake (opioid receptor antagonists, neurokinin-1 receptor antagonists) e whakaatu ana i te oati mo te rongoa i te prurigo nodularis me te iti ake o nga paanga taha ki te thalidomide, lenalidomide ranei.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Ko te Chronic prurigo he mate kiri e tohuhia ana e te patitotanga roa (neke atu i te 6 wiki) , nga whiu kiri e pa ana ki te rakuraku, me te hitori o te rakuraku auau. Kei roto i te neuroinflammation me te fibrosis i roto i te kiri.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Ko te Prurigo nodularis he raruraru kiri roa e tohuhia ana e nga nodule patito. Kaore matou i te tino mohio he aha te take, engari ko te ahua kei te whai waahi nga take aukati me te nerve ki roto i te huringa o te patito. I tenei wa, kaore he maimoatanga i whakaaetia e te US FDA mo te prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Maimoatanga ― OTC Drugs
Ko te horoi i te waahi mate ki te hopi kare e awhina, ka kino ake. Ka awhina pea nga hinu steroid OTC ki te whakaora i nga tohu, engari me tono mo etahi wiki kia pai ake ai. Ko te haere tonu ki te tango i nga antihistamines ka awhina ano hoki ki te whakaora i te mamae.
#OTC steroid ointment
#OTC antihistamine
○ Maimoatanga
#Intralesional triamcinolone injection