Livedoid vasculitis - Livedoid Васкулитис
Livedoid Васкулитис (Livedoid vasculitis) е хронична кожна болест забележана претежно кај млади до средовечни жени. Еден акроним што се користи за да се опишат неговите карактеристики е „Болни пурпурни улцери со ретикуларна шема на долните екстремитети“ (ПОРПРПЛ). Тоа е поврзано со голем број на болести, вклучувајќи хронична венска хипертензија и варикозитети.
☆ Во резултатите на Stiftung Warentest од Германија за 2022 година, задоволството на потрошувачите со ModelDerm беше само малку помало отколку со платените консултации за телемедицина.
Може да биде придружена со болка.
References
Livedoid vasculopathy е ретка состојба на кожата која се карактеризира со болни чирови кои постојано се враќаат на потколениците.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy е ретка состојба на кожата која предизвикува повторливи чирови на потколениците, оставајќи зад себе бледи лузни познати како атрофија бланш. Додека точната причина е сè уште нејасна, се верува дека зголеменото згрутчување на крвта (hypercoagulability) е главниот фактор, при што воспалението игра секундарна улога. Факторите кои придонесуваат за згрутчување го вклучуваат следново - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Во биопсиите, состојбата покажува згрутчување на крвта во садовите, задебелување на ѕидовите на садовите и лузни. Третманот вклучува повеќестран пристап кој се фокусира на спречување на згрутчување на крвта со лекови како антитромбоцитни лекови, разредувачи на крв и фибринолитичка терапија. За оваа состојба на кожата може да се користат различни лекови - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy е ретка состојба каде што се појавуваат лезии на двете нозе. Се смета дека формирањето на згрутчување на крвта во ситните крвни садови е предизвикано од зголемено згрутчување и намалено распаѓање на згрутчувањето, заедно со оштетување на поставата на садот. Почеста е кај жените, особено на возраст од 15 до 50 години. Откажувањето од пушењето, грижата за раните и користењето лекови како што се разредувачи на крв и антитромбоцитни лекови биле ефективни.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
