Livedoid vasculitis - Livedoid Васкулит
Livedoid Васкулит (Livedoid vasculitis) нь залуу болон дунд насны эмэгтэйчүүдэд голчлон илэрдэг арьсны архаг өвчин юм. Түүний онцлогийг тодорхойлоход хэрэглэгддэг товчилсон нэрийн нэг нь "Доод мөчний торлог хэлбэрийн өвдөлттэй идээт шархлаа" (НИЛАГАЛ). Энэ нь архаг венийн гипертензи, венийн судасжилт зэрэг олон тооны өвчинтэй холбоотой байдаг.
☆ Германаас гаргасан 2022 оны Stiftung Warentest-ийн үр дүнгээс үзэхэд ModelDerm-ийн хэрэглэгчдийн сэтгэл ханамж нь төлбөртэй телемедицинийн зөвлөгөө авахаас арай доогуур байв.
Энэ нь өвдөлт дагалдаж болно.
References
Livedoid vasculopathy нь хөлний доод хэсэгт дахин гарч ирдэг өвдөлттэй шархаар тодорхойлогддог арьсны ховор өвчин юм.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy арьсны ховор өвчин бөгөөд хөлний доод хэсэгт дахин шархлаа үүсч, хатингаршил гэж нэрлэгддэг цайвар сорви үлддэг. Яг тодорхой шалтгаан нь тодорхойгүй байгаа ч цусны бүлэгнэлтийн өсөлт (hypercoagulability) нь гол хүчин зүйл бөгөөд үрэвсэл нь хоёрдогч үүрэг гүйцэтгэдэг гэж үздэг. Цусны бүлэгнэлтэд нөлөөлж буй хүчин зүйлүүд нь дараахь зүйлийг агуулдаг - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Биопсийн хувьд энэ нөхцөл байдал нь судаснуудын дотор цусны өтгөрөлт, судасны хана зузаарч, сорвижилтыг харуулдаг. Эмчилгээ нь тромбоцитийн эсрэг эм, цус шингэрүүлэгч, фибринолитик эмчилгээ зэрэг эмийн тусламжтайгаар цусны бүлэгнэлтээс урьдчилан сэргийлэхэд чиглэсэн олон талт арга барилыг агуулдаг. Энэ арьсны өвчинд янз бүрийн эм хэрэглэж болно - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy нь хоёр хөлөнд гэмтэл гардаг ховор тохиолдол юм. Бяцхан судсанд цусны бүлэгнэл үүсэх нь цусны бүлэгнэл нэмэгдэж, цусны бүлэгнэлтийн задрал багассанаас гадна судасны ханыг гэмтээхээс үүдэлтэй гэж үздэг. Энэ нь ялангуяа 15-50 насны эмэгтэйчүүдэд илүү их тохиолддог. Тамхи татахаа болих, шархыг арчлах, цус шингэлэх эм, тромбоцитийн эсрэг эм зэрэг эм хэрэглэх нь үр дүнтэй байдаг.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
