Squamous cell carcinoma - Хавтгай Эсийн Хавдар
☆ Германаас гаргасан 2022 оны Stiftung Warentest-ийн үр дүнгээс үзэхэд ModelDerm-ийн хэрэглэгчдийн сэтгэл ханамж нь төлбөртэй телемедицинийн зөвлөгөө авахаас арай доогуур байв.
Squamous cell carcinoma well differentiated ― Зэргэлдээх актин кератоз ажиглагдаж байна.
References
Squamous cell carcinoma (SCC) нь АНУ-д basal cell carcinoma -ын дараа хоёрдугаарт ордог арьсны хорт хавдар юм. Энэ нь ихэвчлэн actinic keratosis гэж нэрлэгддэг хорт хавдрын өмнөх эмгэгээс эхэлдэг бөгөөд биеийн бусад хэсэгт тархдаг. Гол шалтгаан нь нарны хэт ягаан туяанд өртөж, цаг хугацааны явцад хуримтлагддаг. Эмчилгээ нь ихэвчлэн мэс заслын аргаар зайлуулах, ялангуяа толгой ба хүзүүнд байрлах ХЗХ-ыг арилгахад оршино. Цацрагийн эмчилгээ нь өндөр настай эсвэл мэс засал хийх боломжгүй хүмүүст зориулсан сонголт юм. Дархлаа сулрах нь ХЗХ-ны эрсдлийг нэмэгдүүлдэг. Хэдийгээр ховор тохиолддог боловч ХЗХ ялангуяа дархлаа султай өвчтөнүүдэд тархдаг. ХЗХ-той хүмүүст тогтмол үзлэг хийж, нарнаас хамгаалах нь чухал.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Cutaneous squamous cell carcinoma (CSCC) хүмүүсийн дунд хамгийн их тохиолддог хоёр дахь хорт хавдар бөгөөд түүний тоо нэмэгдсээр байна. Хэдийгээр CSCC нь ихэвчлэн хоргүй эмнэлзүйн зан үйлийг харуулдаг боловч энэ нь орон нутгийн болон биеийн бусад хэсэгт тархаж болно. Эрдэмтэд CSCC-ийн хөгжилд оролцдог тодорхой арга замыг тодорхойлж, шинэ эмчилгээнд хүргэдэг. Дархлаа дарангуйлагдсан өвчтөнүүдэд мутаци их, эрсдэл нэмэгдэж байгаа нь дархлааны эмчилгээг хөгжүүлэхэд түлхэц болсон. Энэхүү тойм нь CSCC-ийн удамшлын үндэс, тодорхой молекулууд болон дархлааны тогтолцоонд чиглэсэн хамгийн сүүлийн үеийн эмчилгээний аргуудыг авч үздэг.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
○ Оношлогоо, эмчилгээ
#Dermoscopy
#Skin biopsy