Lupus erythematosus
☆ Dalam keputusan Stiftung Warentest 2022 dari Jerman, kepuasan pengguna terhadap ModelDerm hanya lebih rendah sedikit berbanding dengan perundingan teleperubatan berbayar.
Ia kelihatan sebagai eritema sedikit keunguan.
Ruam rama-rama yang biasanya muncul di muka.
References
Mengenal pasti dan mengelaskan cutaneous lupus erythematosus (CLE) menimbulkan cabaran diagnostik, membezakannya daripada systemic lupus erythematosus dengan penglibatan kulit. Kajian terkini menjelaskan faktor genetik, persekitaran dan imunologi yang mendasari CLE. Induksi dadah secara khusus telah muncul sebagai salah satu pencetus terpenting untuk CLE. Rawatan melibatkan terapi topikal dan sistemik, termasuk biologi yang menjanjikan seperti belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 , dengan keberkesanan yang ditunjukkan dalam ujian klinikal.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) merangkumi pelbagai masalah kulit, sesetengah daripadanya mungkin dikaitkan dengan masalah kesihatan yang lebih luas. Ia dikategorikan kepada jenis yang berbeza, seperti acute CLE (ACLE) , sub-acute CLE (SCLE) , and chronic CLE (CCLE) . CCLE terdiri daripada discoid lupus erythematosus (DLE) , LE profundus (LEP) , chilblain cutaneous lupus, and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus ialah sekumpulan penyakit autoimun yang boleh menjejaskan bahagian badan yang berlainan. Sesetengah jenis, seperti systemic lupus erythematosus (SLE) , memberi kesan kepada beberapa organ, manakala yang lain, seperti cutaneous lupus erythematosus (CLE) , memberi kesan terutamanya pada kulit. Kami mengkategorikan pelbagai jenis CLE berdasarkan gabungan tanda klinikal, pemeriksaan tisu dan ujian darah, tetapi terdapat banyak variasi antara individu. Masalah kulit sering timbul disebabkan oleh faktor seperti pendedahan kepada cahaya matahari, merokok, atau ubat-ubatan tertentu.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Punca lupus erythematosus tidak jelas. Di kalangan kembar seiras, jika seorang terjejas terdapat 24% kemungkinan yang lain akan turut sama. Hormon seks wanita, cahaya matahari, merokok, kekurangan vitamin D, dan jangkitan tertentu juga dipercayai meningkatkan risiko.
Rawatan mungkin termasuk NSAID, kortikosteroid, imunosupresan, hydroxychloroquine, dan methotrexate. Walaupun kortikosteroid berkesan, penggunaan jangka panjang mengakibatkan kesan sampingan.