Acute generalized exanthematous pustulosis - Pustulosi Eżantematika Ġeneralizzata Akuta
Pustulosi Eżantematika Ġeneralizzata Akuta (Acute generalized exanthematous pustulosis) (AGEP) hija reazzjoni rari tal-ġilda li f'90% tal-każijiet hija relatata mal-għoti tal-medikazzjoni. pustulosi eżantematika ġeneralizzata akuta (acute generalized exanthematous pustulosis) hija kkaratterizzata minn eruzzjonijiet tal-ġilda f'daqqa li jidhru bħala medja ħamest ijiem wara li tinbeda medikazzjoni. Dawn l-eruzzjonijiet huma pustuli, jiġifieri eruzzjoni żgħira aħmar abjad jew aħmar tal-ġilda li jkun fih materjal imdardar jew purulent (pus). Il-leżjonijiet tal-ġilda normalment isolvu fi żmien 1-3 ijiem minn meta titwaqqaf il-medikazzjoni li toffendi.
☆ Fir-riżultati ta' Stiftung Warentest tal-2022 mill-Ġermanja, is-sodisfazzjon tal-konsumatur b'ModelDerm kien biss ftit inqas milli b'konsultazzjonijiet bit-telemediċina mħallsa.
Leżjonijiet mifruxa b'eritema u pustuli jidhru f'daqqa.
References
Acute generalized exanthematous pustulosis (AGEP) hija reazzjoni tal-ġilda mmarkata minn ħotob żgħar mimlijin timbotta fuq bażi tal-ġilda ħamra. Normalment jiġri meta xi ħadd jieħu ċerti mediċini, bħall-antibijotiċi, u jinfirex malajr madwar il-ġisem. Wara li titwaqqaf il-medikazzjoni li tqanqal, is-sintomi tipikament imorru fi żmien ġimagħtejn, u ħafna drabi jħallu xi tixrid tal-ġilda. Għalkemm normalment mhux serji u limitati għall-ġilda, każijiet severi jistgħu jiġu kklassifikati flimkien ma 'reazzjonijiet serji oħra tal-ġilda bħal Stevens-Johnson syndrome jew toxic epidermal necrolysis. It-trattament huwa primarjament kura ta 'appoġġ, u l-pronjosi għal riżoluzzjoni sħiħa tal-marda hija ġeneralment eċċellenti.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Raġel ta’ 76 sena ġie fil-kamra tal-emerġenza minħabba li l-ġilda tiegħu nbidlet f’dawn l-aħħar jumejn. It-tobba sabu irqajja ħomor u żoni mgħollija fuq zokk u dirgħajh u saqajh. Hekk kif għadda ż-żmien, dawn l-irqajja ngħaqdu flimkien, u żviluppa ħotob bħal pimple fiż-żoni ħomor. It-testijiet urew għadd għoli ta’ ċelluli bojod tad-demm b’ħafna tip imsejjaħ newtrofili, u livelli ogħla ta’ C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
