Amyloidosis - Amiloidosi
☆ Fir-riżultati ta' Stiftung Warentest tal-2022 mill-Ġermanja, is-sodisfazzjon tal-konsumatur b'ModelDerm kien biss ftit inqas milli b'konsultazzjonijiet bit-telemediċina mħallsa.
Karatteristiċi klassiċi tal-wiċċ ta' Amiloidosi (Amyloidosis)
References
Mara ta’ 26 sena ġiet il-klinika tagħna tilmenta b’raxx li ħakk f’riġlejha li kellha għal 10 snin. Minkejja li użaw kremi sterojdi u krema tazarotene, ir-raxx ma marretx għall-aħjar. Hija ma kellha l-ebda storja familjari rilevanti. Meta eżaminajnaha, sibna irqajja mgħollija u mhux maħduma fuq quddiem ta’ riġlejha, li kienu jaqblu ma’ marda msejħa lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis hija kundizzjoni rari tal-ġilda marbuta ma' ħakk persistenti ta' kawża mhux magħrufa. Tipikament jidher bħala gruppi ta 'rqajja' mgħollija u skuluriti fuq l-uċuħ ta' barra tal-ġilda. Lichen Amyloidosis normalment jidher f’nies ta’ bejn 50 u 60 sena u sfortunatament, m’hemm l-ebda kura għaliha. It-trattamenti disponibbli issa normalment ma jaħdmux tajjeb.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis hija kundizzjoni ta’ ħakk tal-ġilda fit-tul. Huwa magħruf għall-gruppi ta 'ħotob imħaxxna li jinsabu prinċipalment fuq id-dahar, shins, koxox, u dirgħajn. Meta eżaminat taħt mikroskopju, Lichen amyloidosis juri akkumulazzjoni ta 'amilojde fis-saff ta' fuq tal-ġilda flimkien ma 'tħaxxin u tkabbir tas-saff ta' barra tal-ġilda. Għalkemm il-kawża eżatta ta ' Lichen amyloidosis għadha mhix mifhuma bis-sħiħ, studji preċedenti rabtuha ma' fatturi bħal tħakkik jew frizzjoni fuq il-ġilda, mewt taċ-ċelluli, infezzjonijiet virali, fost oħrajn. Lichen amyloidosis jidher li huwa marbut ma’ diversi kundizzjonijiet oħra tal-ġilda (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
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#Electrophoresis of blood or urine
#Skin biopsy