Drug eruption - Eruzzjoni Tad-Droga
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Eruzzjoni Tad-Droga (Drug eruption) hija kkaratterizzata li taffettwa l-ġisem kollu.
References
Reazzjonijiet tal-ġilda kkawżati minn medikazzjoni, magħrufa bħala eruzzjonijiet tad-droga, xi kultant jistgħu jkunu severi. Dawn ir-reazzjonijiet severi, imsejħa severe cutaneous adverse drug reactions (SCARs) , huma kkunsidrati ta’ theddida għall-ħajja. Dawn jinkludu kundizzjonijiet bħal Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Filwaqt li SCARs huma rari, madwar 2% tal-pazjenti rikoverati l-isptar jesperjenzawhom.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Mara ta’ 31 sena żaret id-dipartiment tad-dermatoloġija b’roqgħa ħamra bla tbatija fuq in-naħa ta’ fuq ta’ sieq il-leminija. Hija ħadet doża waħda ta 'doxycycline (100 mg) il-ġurnata ta' qabel, wara trattament bil-laser picosecond għal ċikatriċi tal-akne. Is-sena li għaddiet, hija esperjenzat kwistjoni simili fl-istess post wara li ħadet l-istess doża ta 'trattament ta' wara l-laser doxycycline. Hija m'għandha l-ebda storja medika sinifikanti u l-ebda sintomi oħra, bħad-deni, lokalment jew madwar ġisimha.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) u toxic epidermal necrolysis (TEN) huma żewġ forom ta’ reazzjoni serja tal-ġilda, differenti minn kundizzjonijiet oħra tal-ġilda bħall-eritema multiforme maġġuri u s-sindromu tal-ġilda mismuta stafilokokkali, kif ukoll reazzjonijiet tad-droga. SJS/TEN hija reazzjoni rari u severa li tikkawża ħsara mifruxa fil-ġilda u fil-membrana mukuża, ħafna drabi b'sintomi sistemiċi. F'aktar minn 80% tal-każijiet, il-mediċini huma l-kawża.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
L-eruzzjonijiet tad-droga huma dijanjostikati prinċipalment mill-istorja medika u l-eżami kliniku. Bijopsija tal-ġilda, testijiet tad-demm jew testijiet immunoloġiċi jistgħu jkunu utli wkoll.
Eżempji ta 'mediċini komuni li jikkawżaw l-eruzzjoni huma antibijotiċi u mediċini antimikrobiċi oħra, mediċini sulfa, mediċini anti-infjammatorji mhux sterojdi (NSAIDs), aġenti ta' kimoterapija għal tumuri malinni, anti-konvulsivi u mediċini psikotropiċi.
○ Djanjosi u Trattament
Jekk għandek deni (żieda fit-temperatura tal-ġisem), għandek tfittex attenzjoni medika kemm jista' jkun malajr. Il-mediċina suspettata għandha titwaqqaf (eż. antibijotiċi, mediċini anti-infjammatorji mhux sterojdi). Qabel ma żżur l-isptar, anti-istaminiċi orali bħal cetirizine jew loratadine jistgħu jgħinu għall-ħakk u r-raxx.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Test tad-demm (CBC, LFT, għadd ta' eosinofili)
Sterojdi orali u anti-istaminiċi bir-riċetta tat-tabib