Livedoid vasculitis - Vaskulite Livedoid
Vaskulite Livedoid (Livedoid vasculitis) hija marda kronika tal-ġilda li tidher b'mod predominanti f'nisa żgħar u ta' età medja. Akronimu wieħed użat biex jiddeskrivi l-karatteristiċi tiegħu huwa "Ulċeri purpuriċi bl-uġigħ b'mudell reticular tal-estremitajiet t'isfel" (VOLA). Huwa assoċjat ma 'numru ta' mard, inkluż pressjoni għolja fil-vini kronika u varikożitajiet.
☆ Fir-riżultati ta' Stiftung Warentest tal-2022 mill-Ġermanja, is-sodisfazzjon tal-konsumatur b'ModelDerm kien biss ftit inqas milli b'konsultazzjonijiet bit-telemediċina mħallsa.
Jista 'jkun akkumpanjat minn uġigħ.
References
Livedoid vasculopathy hija kundizzjoni rari tal-ġilda kkaratterizzata minn ulċeri bl-uġigħ li jibqgħu jiġu lura fuq il-parti t'isfel tar-riġlejn.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy hija kundizzjoni rari tal-ġilda li tikkawża ulċeri rikorrenti fuq ir-riġlejn t'isfel, li tħalli warajha ċikatriċi ċari magħrufa bħala atrophie blanche. Filwaqt li l-kawża eżatta għadha mhix ċara, huwa maħsub li ż-żieda fit-tagħqid tad-demm (hypercoagulability) hija l-fattur ewlieni, bl-infjammazzjoni għandha rwol sekondarju. Fatturi li jikkontribwixxu għat-tagħqid jinkludu kif ġej - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Fil-bijopsiji, il-kundizzjoni turi emboli tad-demm ġewwa l-bastimenti, tħaxxin tal-ħitan tal-bastimenti, u ċikatriċi. It-trattament jinvolvi approċċ fuq diversi punti li jiffoka fuq il-prevenzjoni ta 'emboli tad-demm b'mediċini bħal mediċini kontra l-plejtlits, thinners tad-demm, u terapija fibrinolitika. Jistgħu jintużaw diversi mediċini għal din il-kundizzjoni tal-ġilda - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy hija kundizzjoni rari fejn iseħħu leżjonijiet fuq iż-żewġ saqajn. Il-formazzjoni ta 'emboli tad-demm fil-vini tad-demm ċkejkna hija maħsuba li hija kkawżata minn żieda fit-tagħqid u t-tkissir tal-emboli mnaqqsa, flimkien ma' ħsara lill-kisja tal-bastiment. Huwa aktar komuni fin-nisa, speċjalment bejn l-etajiet 15 u 50. Il-waqfien tat-tipjip, il-kura tal-feriti, u l-użu ta 'mediċini bħal thinners tad-demm u mediċini kontra l-plejtlits kienu effettivi.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
