Porokeratosis - Porokeratożi
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It-truf iebsa li jisporġu 'l barra huma karatteristiċi.
References
Porokeratosis hija kundizzjoni rari tal-ġilda kkaratterizzata minn problemi ta 'keratinizzazzjoni, li tirriżulta f'irqajja' mgħollija f'forma ta' ċirku jew ħotob mhux maħduma fuq il-ġilda. Il-karatteristika li tiddefinixxi taħt il-mikroskopju hija l-preżenza ta 'lamella cornoid, arranġament speċifiku ta' ċelloli fis-saff ta 'fuq tal-ġilda. Porokeratosis jiġi f’diversi forom (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Huwa importanti li wieħed jinnota li porokeratosis jista’ potenzjalment jiżviluppa f’kanċer tal-ġilda. L-aħjar mod biex jiġi djanjostikat porokeratosis huwa permezz ta' bijopsija tal-fruntiera mgħollija, għalkemm bħalissa m'hemm l-ebda protokoll ta' trattament standard.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) hija marda ta' keratinizzazzjoni diżordinata. Huwa wieħed minn sitt tipi ta 'porokeratożi, u tipikament taffettwa żoni akbar meta mqabbla mal-oħrajn (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . It-tip eruttiv ta 'porokeratosis spiss jorbot mal-kanċer, immunità mdgħajfa, jew infjammazzjoni. Fatturi ta 'riskju jinvolvu ġenetika, soppressjoni immuni, u espożizzjoni għax-xemx. DSAP jibda bħala ħotob roża jew kannella bi truf imgħollija f'żoni esposti għax-xemx, xi drabi jikkawżaw ħakk ħafif. It-trattamenti jvarjaw u jistgħu jinkludu kremi topiċi, terapija ħafifa, jew mediċini bħal 5-fluorouracil jew retinojdi. Dawn il-leżjonijiet huma meqjusa bħala prekanċerużi, b' 7. 5 - 10 % ċans li jinbidlu f'karċinoma taċ-ċelluli squamous jew taċ-ċelluli bażali.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Raġel ta’ 52 sena, li qabel kien f’saħħtu, daħal b’garża ċatta, forma ta’ ċirku fuq it-tarf tar-raba’ saqajh, li kien ilu hemm sentejn mingħajr ma jikkawża l-ebda sintomi. Bdiet bħala ħotob żgħir u iebes u kibret 'il barra maż-żmien. Minkejja li ppruvaw diversi trattamenti bħall-krijoterapija, kremi, antifungali, u antibijotiċi, il-garża ma marretx għall-aħjar. Meta teżaminaha mill-qrib b’dermokopsja, wera ċentru niexef u aħmar b’bord oħxon u mhux maħdum. Biċċa ċkejkna tal-ġilda meħuda mit-tarf tal-garża wriet tkabbir anormali taċ-ċelluli fis-saff ta 'barra tal-ġilda, li tikkonferma dijanjosi ta' porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Ħafna drabi ssir bijopsija minħabba li tista' tidher simili għal keratożi aktinika jew karċinoma taċ-ċelluli squamous.