Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) एक दुर्लभ छाला प्रतिक्रिया हो जुन 90% केसहरूमा औषधि प्रशासनसँग सम्बन्धित छ। acute generalized exanthematous pustulosis अचानक छाला विष्फोटको विशेषता हो जुन औषधि सुरु भएको औसत पाँच दिन पछि देखा पर्दछ। यी विस्फोटहरू पुस्ट्युलहरू हुन्, अर्थात् छालाको सानो रातो सेतो वा रातो विष्फोट जसमा बादल छ वा प्युलेन्ट सामग्री (पस) हुन्छ। छालाको घाउ सामान्यतया अपमानजनक औषधि बन्द गरेको १-३ दिन भित्र समाधान हुन्छ।
☆ जर्मनीबाट 2022 Stiftung Warentest नतिजाहरूमा, ModelDerm सँग उपभोक्ता सन्तुष्टि सशुल्क टेलिमेडिसिन परामर्शको तुलनामा थोरै मात्र थियो।
एरिथिमा र पुस्टुल्सका साथ व्यापक घाउहरू अचानक देखा पर्छन्।
References
Acute generalized exanthematous pustulosis (AGEP) छालाको प्रतिक्रिया हो जुन रातो छालाको आधारमा सानो, पुसले भरिएको बम्पहरू द्वारा चिन्हित हुन्छ। यो सामान्यतया तब हुन्छ जब कसैले एन्टिबायोटिक जस्ता निश्चित औषधिहरू लिन्छ र छिट्टै शरीरभर फैलिन्छ। ट्रिगर गर्ने औषधि बन्द गरेपछि, लक्षणहरू सामान्यतया दुई हप्ता भित्र टाढा जान्छन्, प्रायः केही छालाको बहाव छोडेर। यद्यपि सामान्यतया गम्भीर र छालामा सीमित छैन, गम्भीर केसहरूलाई अन्य गम्भीर छाला प्रतिक्रियाहरू जस्तै Stevens-Johnson syndrome वा toxic epidermal necrolysis सँगसँगै वर्गीकृत गर्न सकिन्छ। उपचार मुख्यतया सहायक हेरचाह हो, र रोग को पूर्ण समाधान को लागी प्रोग्नोसिस सामान्यतया उत्कृष्ट छ।
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
एक 76 वर्षीय व्यक्ति आपतकालीन कोठामा आए किनभने उनको छाला विगत दुई दिनमा परिवर्तन भएको थियो। डाक्टरहरूले उनको पेट र हात र खुट्टामा रातो दाग र उठेको क्षेत्रहरू फेला पारे। समय बित्दै जाँदा, यी प्याचहरू एकसाथ जोडिए, र उसले रातो क्षेत्रमा पिम्पल-जस्तै बम्पहरू विकास गर्यो। परीक्षणहरूले न्युट्रोफिल भनिने धेरै प्रकारका साथ उच्च सेतो रक्त कोशिकाहरूको संख्या र C-reactive protein को बढेको स्तर देखायो।
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
