Drug eruption
☆ जर्मनीबाट 2022 Stiftung Warentest नतिजाहरूमा, ModelDerm सँग उपभोक्ता सन्तुष्टि सशुल्क टेलिमेडिसिन परामर्शको तुलनामा थोरै मात्र थियो।
Drug eruption सम्पूर्ण शरीरलाई असर गर्ने विशेषता हो।
References
औषधिको कारणले हुने छालाको प्रतिक्रिया, जसलाई ड्रग विष्फोट भनिन्छ, कहिलेकाहीँ गम्भीर हुन सक्छ। यी गम्भीर प्रतिक्रियाहरू, severe cutaneous adverse drug reactions (SCARs) भनिन्छ, जीवन-खतरा मानिन्छ। तिनीहरूमा Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) जस्ता सर्तहरू समावेश छन्। जबकि SCARs दुर्लभ छन्, अस्पतालमा भर्ना भएका बिरामीहरूको लगभग 2% ले तिनीहरूको अनुभव गर्छन्।
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
एक ३१ वर्षीया महिला आफ्नो दाहिने खुट्टाको माथिल्लो भागमा पीडाविहीन रातो दाग भएको छालारोग विभागमा पुगिन्। उनले एक दिन अघि डक्सीसाइक्लिन (100 मिलीग्राम) को एक खुराक लिए, मुँहासे दाग लागि पिकोसेकेन्ड लेजर उपचार पछि। गत वर्ष, उनले डोक्सीसाइक्लिन पोस्ट-लेजर उपचारको एउटै डोज लिएपछि उही ठाउँमा यस्तै समस्या अनुभव गरे। उनको कुनै महत्त्वपूर्ण चिकित्सा इतिहास छैन र अन्य कुनै लक्षणहरू छैनन्, जस्तै ज्वरो, स्थानीय रूपमा वा उनको शरीरभरि।
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) र toxic epidermal necrolysis (TEN) गम्भीर छाला प्रतिक्रियाका दुई रूपहरू हुन्, अन्य छाला अवस्थाहरू जस्तै erythema multiforme major र staphylococcal scalded skin syndrome, साथै ड्रग प्रतिक्रियाहरू भन्दा फरक। SJS/TEN एक दुर्लभ र गम्भीर प्रतिक्रिया हो जसले छाला र श्लेष्म झिल्लीलाई व्यापक क्षति पुर्याउँछ, प्रायः प्रणालीगत लक्षणहरू सहित। 80% भन्दा बढी अवस्थामा, औषधि कारण हो।
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
औषधि विष्फोट मुख्यतया चिकित्सा इतिहास र क्लिनिकल परीक्षा बाट निदान गरिन्छ। छालाको बायोप्सी, रक्त परीक्षण वा इम्युनोलोजिकल परीक्षणहरू पनि उपयोगी हुन सक्छन्।
एन्टिबायोटिक्स र अन्य एन्टिमाइक्रोबियल ड्रग्स, सल्फा ड्रग्स, ननस्टेरोइडल एन्टि-इन्फ्लेमेटरी ड्रग्स (NSAIDs), केमोथेरापी एजेन्टहरू, एन्टिकन्भल्सेन्ट्स र साइकोट्रोपिक ड्रगहरू विस्फोट गराउने सामान्य औषधिहरूका उदाहरणहरू हुन्।
○ निदान र उपचार
यदि तपाईलाई ज्वरो आएको छ (शरीरको तापक्रम बढेको छ), तपाईले जतिसक्दो चाँडो चिकित्सकीय ध्यान खोज्नुपर्छ। शंकास्पद औषधि बन्द गरिनुपर्छ (जस्तै एन्टिबायोटिक्स, गैर-स्टेरोइडल एन्टि-इन्फ्लेमेटरी ड्रग्स)। अस्पताल जानु अघि, मौखिक एन्टिहिस्टामाइनहरू जस्तै cetirizine वा loratadine ले चिलाउने र दाग लागि मद्दत गर्न सक्छ।
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
रक्त परीक्षण (सीबीसी, एलएफटी, इओसिनोफिल गणना)
डाक्टरको प्रिस्क्रिप्शनको साथ मौखिक स्टेरोइडहरू र एन्टिहिस्टामिनहरू