Toxic epidermal necrosis - विषाक्त एपिडर्मल नेक्रोसिस
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विषाक्त एपिडर्मल नेक्रोसिस (Toxic epidermal necrosis) को विशेषता छाला हानि
References
Stevens-Johnson Syndrome (SJS) र Toxic Epidermal Necrolysis (TEN) दुर्लभ अवस्थाहरू हुन् जहाँ छालाले व्यापक नेक्रोसिस र शेडिङ अनुभव गर्दछ। उपचारको सन्दर्भमा, साइक्लोस्पोरिन SJS को लागि अत्यधिक प्रभावकारी छ, जबकि Intravenous immunoglobulin (IVIg) र corticosteroids को संयोजन SJS र TEN को लागि राम्रो काम गर्दछ।
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) केही औषधिहरू र प्रतिरक्षा प्रणाली गतिविधिको कारणले गर्दा हुने गम्भीर छालाको प्रतिक्रिया हो, जसको परिणाम स्वरूप बाहिरी छालाको तह (एपिडर्मिस) को ठूलो मात्रामा टुक्राटुक्रा हुन्छ, जसले शरीरको सतहको 30% भन्दा बढीलाई असर गर्छ। TEN मा 20% भन्दा बढीको मृत्यु दर छ, प्रायः संक्रमण र सास फेर्न कठिनाइको कारणले। प्रतिक्रिया निम्त्याउने औषधि रोक्न, सहायक हेरचाह प्रदान गर्न, र थप उपचारहरू प्रयोग गरेर परिणाम सुधार गर्न सक्छ। भर्खरैका अध्ययनहरूले देखाएको छ कि साइक्लोस्पोरिन, ट्युमर नेक्रोसिस कारक अल्फा अवरोधकहरू, र इन्टरभेनस इम्यून ग्लोब्युलिन र कोर्टिकोस्टेरोइडहरूको संयोजन जस्ता औषधिहरू उपयोगी हुन सक्छन्, अनियमित नियन्त्रित परीक्षणहरू र बहुविध अध्ययनहरूको विश्लेषणहरूमा आधारित।
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
सबैभन्दा सामान्य कारण केही औषधिहरू जस्तै ल्यामोट्रिजिन, कार्बामाजेपाइन, एलोप्युरिनोल, सल्फोनामाइड एन्टिबायोटिक्स र नेभिरापाइन हुन्। जोखिम कारकहरु मा एचआईभी र प्रणालीगत लुपस erythematosus समावेश छ। उपचार सामान्यतया अस्पतालमा गरिन्छ जस्तै बर्न युनिट वा गहन हेरचाह इकाईमा।
○ उपचार
यो एक गम्भीर रोग हो, त्यसैले यदि तपाईंको ओठ वा मुख प्रभावित भएको छ वा तपाईंको छालामा छाला परेको छ भने, सकेसम्म चाँडो आफ्नो डाक्टरलाई हेर्नुहोस्।
शंकास्पद औषधिहरू बन्द गर्नुपर्छ। (जस्तै एन्टिबायोटिक्स, गैर-स्टेरोइडल एन्टि-इन्फ्लेमेटरी ड्रग्स)