Livedoid vasculitis
Livedoid vasculitis is een chronische huidziekte die voornamelijk voorkomt bij vrouwen van jonge tot middelbare leeftijd. Een acroniem dat wordt gebruikt om de kenmerken ervan te beschrijven is "Pijnlijke purpurische zweren met een reticulair patroon van de onderste ledematen" (PAARS). Het wordt in verband gebracht met een aantal ziekten, waaronder chronische veneuze hypertensie en spataderen.
☆ Uit de resultaten van de Stiftung Warentest uit Duitsland uit 2022 bleek dat de consumententevredenheid over ModelDerm slechts iets lager was dan over betaalde telegeneeskundeconsulten.
Het kan gepaard gaan met pijn.
References
Livedoid vasculopathy is een zeldzame huidaandoening die wordt gekenmerkt door pijnlijke zweren die steeds terugkomen op de onderbenen.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy is een zeldzame huidaandoening die terugkerende zweren op de onderbenen veroorzaakt, waardoor bleke littekens achterblijven die bekend staan als atrofie blanche. Hoewel de exacte oorzaak nog steeds onduidelijk is, wordt aangenomen dat een verhoogde bloedstolling (hypercoagulability) de belangrijkste factor is, waarbij ontstekingen een secundaire rol spelen. Factoren die bijdragen aan de stolling zijn onder meer: deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Bij biopsieën vertoont de aandoening bloedstolsels in de bloedvaten, verdikking van de vaatwanden en littekens. De behandeling omvat een veelzijdige aanpak die zich richt op het voorkomen van bloedstolsels met medicijnen zoals bloedplaatjesaggregatieremmers, bloedverdunners en fibrinolytische therapie. Voor deze huidaandoening kunnen verschillende medicijnen worden gebruikt - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is een zeldzame aandoening waarbij laesies aan beide benen voorkomen. Er wordt aangenomen dat de vorming van bloedstolsels in kleine bloedvaten wordt veroorzaakt door verhoogde stolling en verminderde afbraak van stolsels, samen met schade aan de vaatwand. Het komt vaker voor bij vrouwen, vooral tussen de 15 en 50 jaar. Stoppen met roken, het verzorgen van wonden en het gebruik van medicijnen zoals bloedverdunners en bloedplaatjesaggregatieremmers zijn effectief geweest.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
