Acanthosis nigricans
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References
Acanthosis nigricans er en kutan manifestasjon av en underliggende tilstand. Det vises ofte i hudfolder som nakke, armhuler og lyske, og ser ut som fløyelsmyke mørke flekker med uklare kanter. Denne tilstanden er vanligvis knyttet til diabetes og insulinresistens, men i sjeldne tilfeller kan det peke på kreft inne i kroppen. Det kan også dukke opp på grunn av hormonproblemer eller ved å ta spesifikke medisiner som steroider og p-piller.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) er en vanlig hudtilstand knyttet til ulike helseproblemer som insulinresistens, diabetes, fedme, visse kreftformer, hormonelle problemer og reaksjoner på medisiner. Behandling av AN fokuserer på å adressere de underliggende helseproblemene. Til å begynne med sjekker leger etter tegn på insulinresistenssyndrom, som inkluderer fedme, høyt kolesterol, høyt blodtrykk og type 2 diabetes. Leger foreskriver ofte topical retinoids som første behandlingsvalg, noe som kan hjelpe mot fortykning av huden. Imidlertid kan det hende de ikke fullt ut adresserer mørkfarging av huden. Andre behandlingsalternativer (salicylic acid, podophyllin, urea, calcipotriol) trenger også hyppig påføring.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
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Det forekommer vanligvis hos individer yngre enn 40 år, kan være genetisk arvelig og er assosiert med fedme eller endokrinopatier, som hypotyreose, akromegali, polycystisk eggstokksykdom, insulinresistent diabetes eller Cushings sykdom.
○ Behandling ― OTC-medisiner
#40% urea cream