Amyloidosis - Amyloidose
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I 2022 Stiftung Warentest-resultatene fra Tyskland var forbrukertilfredsheten med ModelDerm bare litt lavere enn med betalte telemedisinkonsultasjoner.
I 2022 Stiftung Warentest-resultatene fra Tyskland var forbrukertilfredsheten med ModelDerm bare litt lavere enn med betalte telemedisinkonsultasjoner.
Klassiske ansiktstrekk ved amyloidose (Amyloidosis)
relevance score : -100.0%
ReferencesEn 26 år gammel kvinne kom til klinikken vår og klaget over et kløende utslett på bena som hun hadde hatt i ti år. Til tross for bruk av steroidkremer og tazarotenkrem, ble ikke utslettet bedre. Hun hadde ingen relevant familiehistorie. Da vi undersøkte henne, fant vi hevede, grove flekker på forsiden av bena hennes som samsvarte med en sykdom kalt lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis er en sjelden hudtilstand som er knyttet til vedvarende kløe av ukjent årsak. Tilstanden viser seg vanligvis som klynger av hevede, misfargede flekker på hudens ytre overflater. Lichen Amyloidosis forekommer mest hos personer i alderen 50–60 år, og dessverre finnes det ingen kur. De behandlingene som er tilgjengelige i dag, gir ofte begrenset effekt.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis er en kronisk, kløende hudtilstand. Den kjennetegnes av klynger av fortykkede, ujevne papler som hovedsakelig forekommer på rygg, legg, lår og armer. Når den undersøkes mikroskopisk, viser Lichen amyloidosis en opphopning av amyloid i det øverste hudlaget, samt fortykkelse og forstørrelse av det ytre hudlaget. Selv om den eksakte årsaken ikke er fullt forstått, har tidligere studier knyttet tilstanden til faktorer som friksjon på huden, celledød, virusinfeksjoner og lignende. Lichen amyloidosis ser også ut til å være assosiert med flere andre hudsykdommer, som atopisk dermatitt (atopic dermatitis), lichen planus og mykose fungoides (mycosis fungoides).
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnose og behandling
#Electrophoresis of blood or urine
#Skin biopsy