Erythema nodosum
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Det vises som en smertefull erytematøs knute på benet.
References
Erythema nodosum er den vanligste typen pannikulitt, preget av smertefulle røde knuter, hovedsakelig funnet på underbena. Den eksakte årsaken er fortsatt ukjent, men den ser ut til å være resultatet av en overdreven respons på forskjellige utløsere. Selv om opprinnelsen ofte er usikker, er det viktig å utelukke andre underliggende tilstander før du diagnostiserer primary erythema nodosum. Det kan indikere utbruddet av systemiske sykdommer som infeksjoner, betennelser, kreft eller reaksjoner på medisiner. Vanlige utløsere inkluderer strep infections, tuberculosis, sarcoidosis, Behçet's disease, inflammatory bowel disease, certain medications, pregnancy.
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis refererer til et mangfoldig sett av inflammatoriske tilstander som påvirker fettvevet under huden. Disse tilstandene er uvanlige hos barn. Panniculitis kan enten være hovedproblemet i en systemisk tilstand eller en reaksjon sekundært til faktorer som infeksjon, skade eller visse medisiner. Uavhengig av årsak viser de fleste typer panniculitis lignende symptomer, inkludert smertefulle, røde knuter under huden.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , en betennelse i fettlaget under huden, er en sjelden tilstand som vanligvis viser seg som hovne knuter eller flekker. Erythema nodosum (EN) er den vanligste typen, ofte utløst av ulike faktorer. Mens rundt 55 % av tilfellene ikke har noen klar årsak, inkluderer vanlige triggere infeksjoner, medisiner, visse sykdommer som sarkoidose og inflammatorisk tarmsykdom, graviditet og kreft. EN vises vanligvis hos tenåringer og unge voksne, oftere hos kvinner. Det innledes ofte med en generell sykdomsfølelse som varer i én til tre uker, med symptomer som feber og problemer med øvre luftveier. Deretter vises røde knuter, vanligvis på de ytre sidene av armer og ben, og forårsaker smerte. ENs eksakte årsak er ikke fullt ut forstått, men det antas å involvere immunkomplekser i små blodårer i fettlaget, noe som fører til betennelse. Vanligvis viser en biopsi betennelse i fettlaget uten skade på blodårene. Selv uten spesifikk behandling for den underliggende årsaken, løser EN ofte av seg selv. Så de fleste pasienter trenger bare støttende behandling for symptomene sine.
Panniculitis, an inflammation of the fat layer under the skin, is a rare condition usually showing up as swollen nodules or patches. Erythema nodosum (EN) is the most common type, often triggered by various factors. While around 55% of cases have no clear cause, common triggers include infections, medications, certain diseases like sarcoidosis and inflammatory bowel disease, pregnancy, and cancer. EN usually appears in teens and young adults, more often in females. It's often preceded by a general feeling of illness lasting one to three weeks, with symptoms like fever and upper respiratory issues. Then, red nodules appear, usually on the outer sides of arms and legs, causing pain. EN's exact cause isn't fully understood, but it's believed to involve immune complexes in small blood vessels of the fat layer, leading to inflammation. Typically, a biopsy shows inflammation in the fat layer without damage to blood vessels. Even without specific treatment for the underlying cause, EN often resolves on its own. So, most patients need only supportive care for their symptoms.
Panniculitis, an inflammation of the fat layer under the skin, is a rare condition usually showing up as swollen nodules or patches. Erythema nodosum (EN) is the most common type, often triggered by various factors. While around 55% of cases have no clear cause, common triggers include infections, medications, certain diseases like sarcoidosis and inflammatory bowel disease, pregnancy, and cancer. EN usually appears in teens and young adults, more often in females. It's often preceded by a general feeling of illness lasting one to three weeks, with symptoms like fever and upper respiratory issues. Then, red nodules appear, usually on the outer sides of arms and legs, causing pain. EN's exact cause isn't fully understood, but it's believed to involve immune complexes in small blood vessels of the fat layer, leading to inflammation. Typically, a biopsy shows inflammation in the fat layer without damage to blood vessels. Even without specific treatment for the underlying cause, EN often resolves on its own. So, most patients need only supportive care for their symptoms.
Erythema nodosum diagnostiseres klinisk. En biopsi kan tas og undersøkes mikroskopisk for å bekrefte en usikker diagnose. Røntgen av thorax bør utføres for å utelukke lungesykdommer, spesielt sarkoidose og tuberkulose.