Lymphangioma - Lymfangiom
Lymfangiom (Lymphangioma) er misdannelser i lymfesystemet preget av lesjoner som er tynnveggede cyster. Disse misdannelsene kan oppstå i alle aldre og kan involvere hvilken som helst del av kroppen, men 90 % forekommer hos barn under 2 år og involverer hode og nakke. Lymfangiomer diagnostiseres ofte før fødselen ved hjelp av føtal ultralyd. Ervervede lymfangiom kan skyldes traumer, betennelse eller lymfatisk obstruksjon. Siden de ikke har noen sjanse til å bli ondartede, behandles lymfangiomer vanligvis kun av kosmetiske årsaker.
☆ I 2022 Stiftung Warentest-resultatene fra Tyskland var forbrukertilfredsheten med ModelDerm bare litt lavere enn med betalte telemedisinkonsultasjoner.
References
Lymphangioma er også kjent som lymfatisk misdannelse (LM) . Det er en vaskulær lidelse som er tilstede fra fødselen. Det er preget av unormal vekst av lymfatisk vev før og etter fødselen. Lymphangioma påvirker omtrent 1 av 2000 til 4000 mennesker, uten noen signifikant forskjell mellom kjønn eller raser. De fleste tilfeller (80–90 %) diagnostiseres før to år. Symptomene varierer mye, fra lokal hevelse til omfattende abnormiteter i lymfekanalene, noen ganger fører til alvorlig hevelse kjent som elefantiasis. For eksempel kan lymphangioma i nakken og ansiktet forårsake ansiktshevelse, og i alvorlige tilfeller vansiring. Når det påvirker tungen, kan det føre til kjeveovervekst og feiljusterte tenner. I munn og nakke kan det forårsake pusteproblemer og livstruende nødsituasjoner. I øynene kan det forårsake synstap, begrenset øyebevegelse, hengende øyelokk og svulmende øyne. Involvering av lemmer kan forårsake hevelse og unormal vekst av vev og bein. Denne svulsten vokser vanligvis sakte, men infeksjoner, hormonelle endringer eller skader kan forårsake rask vekst, og utgjøre livstruende risikoer som krever akutt behandling.
Lymphangioma (lymphatic malformation, LM), a congenital vascular disease, is a low-flow vascular abnormality in lymphatic diseases that is characterized by excessive growth of lymphatic tissue during prenatal and postpartum development. The incidence rate of LM is ~1:2000–4000, with no variation between genders and races. Most patients (80–90%) are diagnosed before the age of two. The clinical manifestations of lymphangioma are quite different among patients, varying from local swelling leading to superficial mass to a large area of diffuse infiltrating lymphatic channel abnormalities resulting in elephantiasis. Cervicofacial LM can cause facial elephantiasis, and in some severe cases, it can lead to serious disfigurement of the face. Tongue LM can lead to mandibular overgrowth and occlusal asymmetry, and oral and cervical LM can cause obstructive acute respiratory distress and life-threatening situations. Orbital LM may lead to decreased vision, decreased extraocular muscle movement, ptosis and exophthalmos. LM of the extremities can trigger swelling or gigantism, accompanied by overgrowth of soft tissue and bones. LM usually grows slowly and steadily, but under certain conditions, such as infection, hormonal changes or trauma, it can grow explosively and become a life-threatening disease requiring immediate treatment.
Lymphangioma (lymphatic malformation, LM), a congenital vascular disease, is a low-flow vascular abnormality in lymphatic diseases that is characterized by excessive growth of lymphatic tissue during prenatal and postpartum development. The incidence rate of LM is ~1:2000–4000, with no variation between genders and races. Most patients (80–90%) are diagnosed before the age of two. The clinical manifestations of lymphangioma are quite different among patients, varying from local swelling leading to superficial mass to a large area of diffuse infiltrating lymphatic channel abnormalities resulting in elephantiasis. Cervicofacial LM can cause facial elephantiasis, and in some severe cases, it can lead to serious disfigurement of the face. Tongue LM can lead to mandibular overgrowth and occlusal asymmetry, and oral and cervical LM can cause obstructive acute respiratory distress and life-threatening situations. Orbital LM may lead to decreased vision, decreased extraocular muscle movement, ptosis and exophthalmos. LM of the extremities can trigger swelling or gigantism, accompanied by overgrowth of soft tissue and bones. LM usually grows slowly and steadily, but under certain conditions, such as infection, hormonal changes or trauma, it can grow explosively and become a life-threatening disease requiring immediate treatment.
I denne retrospektive studien gjennomgikk vi 24 barn som hadde lymphangioma og ble behandlet med injeksjoner av bleomycinløsning fra januar 1999 til desember 2004. De fleste lesjonene (63 %) gikk helt bort, 21 % fikk god respons og 16 % svarte ikke bra. To pasienter fikk svulsten tilbake senere, og to andre fikk abscesser der de fikk injeksjonene. Heldigvis så vi ingen andre store problemer eller bivirkninger.
This is a retrospective study of 24 children diagnosed with lymphangioma and treated with intralesional injection of bleomycin aqueous solution from January 1999 to December 2004. Complete resolution was seen in 63% (15/24) of lesions, 21% (5/24) had good response and 16% (4/24) had poor response. The tumour recurred in 2 patients. Two other patients had abscess formation at the site of injection. No other serious complications or side effects were observed.
This is a retrospective study of 24 children diagnosed with lymphangioma and treated with intralesional injection of bleomycin aqueous solution from January 1999 to December 2004. Complete resolution was seen in 63% (15/24) of lesions, 21% (5/24) had good response and 16% (4/24) had poor response. The tumour recurred in 2 patients. Two other patients had abscess formation at the site of injection. No other serious complications or side effects were observed.
Hovedtypene av lymphangioma er som følger - lymphangioma circumscriptum, cavernous lymphangioma, cystic hygroma, lymphangioendothelioma. Disse utgjør rundt 26 % av godartede vaskulære svulster hos barn, men er mindre vanlige hos voksne. Lymphangioma circumscriptum , den hyppigste typen, viser lymfekanaler som stikker ut gjennom huden og danner klare væskefylte vesikler som ligner på froskegyter, sammen med hevelse i vevet. Det vises vanligvis på områder med et rikt lymfatisk nettverk som lemmer, bagasjerom og armhuler. En 71 år gammel kvinne kom til klinikken vår med vedvarende hevelser i bena, rosa kuler på kjønnsorganene, kløe og lekkasje av lymfevæske. Vi fjernet kirurgisk alle ujevnheter med en prosedyre kalt bilateral major labiectomy, stoppet på Colles' fascia-nivå, mens vi bevarte klitoris og fourchette.
The predominant types of lymphangioma are lymphangioma circumscriptum (LC), cavernous lymphangioma, cystic hygroma, and lymphangioendothelioma. These entities account for approximately 26% of benign vascular tumors in children but are rarer in adults. LC is the most common form of cutaneous lymphangioma and is characterized by superficial lymphatic ducts protruding through the epidermis. This condition results in clusters of clear fluid-filled vesicles resembling frog spawn and associated tissue edema. It is usually found on the proximal extremity, trunk, and axilla, which has an abundant lymphatic system. A 71-year-old female presented to our outpatient clinic with persistent edema of both lower limbs, clusters of pink labial papules, pruritus, and watery lymph oozing. We removed all the papules by performing bilateral major labiectomy down to the level of Colles' fascia, sparing the clitoris and fourchette.
The predominant types of lymphangioma are lymphangioma circumscriptum (LC), cavernous lymphangioma, cystic hygroma, and lymphangioendothelioma. These entities account for approximately 26% of benign vascular tumors in children but are rarer in adults. LC is the most common form of cutaneous lymphangioma and is characterized by superficial lymphatic ducts protruding through the epidermis. This condition results in clusters of clear fluid-filled vesicles resembling frog spawn and associated tissue edema. It is usually found on the proximal extremity, trunk, and axilla, which has an abundant lymphatic system. A 71-year-old female presented to our outpatient clinic with persistent edema of both lower limbs, clusters of pink labial papules, pruritus, and watery lymph oozing. We removed all the papules by performing bilateral major labiectomy down to the level of Colles' fascia, sparing the clitoris and fourchette.
