Drug eruption
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Drug eruption imadziwika ndi kukhudza thupi lonse.
References
Khungu lomwe limayamba chifukwa cha mankhwala, lomwe limadziwika kuti kuphulika kwa mankhwala, nthawi zina limakhala lowopsa. Zowopsa izi, zotchedwa severe cutaneous adverse drug reactions (SCARs) , zimawonedwa ngati zowopseza moyo. Zimaphatikizapo zinthu ngati Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Ngakhale SCARs ndizosowa, pafupifupi 2% ya odwala omwe ali m'chipatala amakumana nawo.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Mayi wina wazaka 31 anapita ku dipatimenti ya dermatology ali ndi chigamba chofiira chosapweteka pamwamba pa phazi lake lakumanja. Anamwa mlingo umodzi wa doxycycline (100 mg) dzulo lake, kutsatira mankhwala a picosecond laser a zipsera. Chaka chatha, adakumana ndi vuto lofananalo pamalo omwewo atamwa mankhwala omwewo a doxycycline pambuyo pa laser. Alibe mbiri yakale yachipatala ndipo alibe zizindikiro zina, monga kutentha thupi, kwanuko kapena thupi lonse.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) ndi toxic epidermal necrolysis (TEN) ndi mitundu iwiri ya vuto lalikulu la khungu, losiyana ndi matenda ena a khungu monga erythema multiforme yaikulu ndi staphylococcal scalded skin syndrome, komanso zotsatira za mankhwala. SJS/TEN ndizovuta komanso zowopsa zomwe zimayambitsa kuwonongeka kwa khungu ndi mucous nembanemba, nthawi zambiri ndi zizindikiro za systemic. Mu 80% ya milandu, mankhwala ndi omwe amachititsa.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Kuphulika kwa mankhwala kumapezeka makamaka kuchokera ku mbiri yachipatala ndi kufufuza kwachipatala. Kupimidwa pakhungu, kuyezetsa magazi kapena kuyezetsa chitetezo cha mthupi kungathandizenso.
Zitsanzo za mankhwala omwe amayambitsa kuphulika ndi maantibayotiki ndi mankhwala ena oletsa tizilombo toyambitsa matenda, mankhwala a sulfa, nonsteroidal anti-inflammatory drugs (NSAIDs), chemotherapy agents for malignancies, anticonvulsants ndi psychotropic mankhwala.
○ Kuzindikira ndi Chithandizo
Ngati muli ndi malungo (kuwonjezeka kwa kutentha kwa thupi), muyenera kupita kuchipatala mwamsanga. Mankhwala omwe akuganiziridwawo ayenera kusiyidwa (mwachitsanzo, maantibayotiki, non-steroidal anti-inflammatory drugs). Musanapite kuchipatala, mankhwala oletsa antihistamine monga cetirizine kapena loratadine angathandize kuyabwa ndi zidzolo.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Kuyeza magazi (CBC, LFT, eosinophil count)
Oral steroids ndi antihistamines ndi mankhwala a dokotala