Dysplastic nevus
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Dysplastic nevi ― Biopsy ndiyovomerezeka kwa aku Western.
References
Dysplastic nevus , yomwe imadziwikanso kuti atypical kapena Clarks nevus, yayambitsa mikangano mu dermatology ndi dermatopathology. Madokotala nthawi zambiri amawunika timadontho tinthu tating'onoting'ono tating'onoting'ono chifukwa amatha kuwoneka ngati achilendo ndikudzutsa nkhawa za melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , yomwe imadziwikanso kuti atypical kapena Clark nevi, nthawi zina imatha kuyambitsa melanoma. Pafupifupi 36% ya melanomas amapezeka pafupi ndi dysplastic nevi. Zizindikiro zosonyeza kuti dysplastic nevus ingasinthe kukhala melanoma imaphatikizapo mawonekedwe osagwirizana, kusintha kwa mtundu, kapena mtundu wotuwa. Khansara imeneyi nthawi zambiri imachitika ali aang'ono (cha m'ma 30) , amatha kukhala angapo, ndipo nthawi zambiri amakhala pa thunthu. Mwachibadwa, dysplastic nevi ali pakati pa benign nevi ndi melanoma. Komabe, 20% mpaka 30% yokha ya melanomas imachokera ku nevi yomwe ilipo kale. Popeza ambiri a nevi sakhala melanoma, sikoyenera kuwachotsa modziteteza.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma ndi mtundu wa chotupa chomwe chimapanga pamene ma melanocyte, maselo omwe amachititsa khungu, amakhala ndi khansa. Ma melanocyte amachokera ku neural crest. Izi zikutanthauza kuti melanomas imatha kukula osati pakhungu lokha komanso m'malo ena omwe maselo a neural crest amasamukira, monga m'mimba ndi ubongo. Kupulumuka kwa odwala omwe ali ndi melanoma yoyambirira (gawo 0) ndipamwamba kwambiri pa 97%, pomwe amatsika kwambiri mpaka pafupifupi 10% kwa omwe amapezeka ndi matenda apamwamba (siteji IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Cancer chiopsezo
Monga momwe zimawonera anthu a ku Caucasus ku United States, omwe ali ndi dysplastic nevi ali ndi chiopsezo cha moyo wonse chokhala ndi melanoma yoposa 10%. Komano, omwe alibe dysplastic nevus ali pachiwopsezo chokhala ndi melanoma yochepera 1%.
○ Precaution kwa anthu omwe ali ndi dysplastic nevi
Kudzipenda pakhungu nthawi zambiri kumalimbikitsidwa popewa khansa ya melanoma (pozindikira nevi ya atypical yomwe ingachotsedwe) kapena kuzindikira msanga zotupa zomwe zilipo. Anthu omwe ali ndi mbiri yapaokha kapena banja lawo la khansa yapakhungu kapena atypical nevi angapo ayenera kuwona dermatologist kamodzi pachaka kuti atsimikizire kuti sakudwala melanoma.
Chidulechi [ABCDE] chakhala chothandiza pothandiza othandizira azaumoyo komanso anthu wamba kukumbukira mikhalidwe yayikulu ya melanoma. Tsoka ilo kwa munthu wamba, ma seborrheic keratoses ambiri, ma lentigo senilis, ngakhale njerewere zimatha kukhala ndi [ABCDE], ndipo sizingasiyanitsidwe ndi melanoma.
○ [ABCDE]
Asymmetrical: Asymmetrical chotupa pakhungu.
Border: Malire a chotupacho ndi osakhazikika.
Color: Ma melanoma nthawi zambiri amakhala ndi mitundu ingapo yosiyana.
Diameter: Nevi wamkulu kuposa 6 mm ali ndi mwayi wokhala ndi melanomas kuposa ang'onoang'ono.
Evolution: Kusintha (i.e. kusintha) kwa nevus kapena zilonda kungasonyeze kuti chotupacho chikukhala choopsa.