Keloid
☆ Muzotsatira za 2022 Stiftung Warentest zochokera ku Germany, kukhutitsidwa kwa ogula ndi ModelDerm kunali kotsika pang'ono kusiyana ndi kuyankhulana kwa telemedicine komwe kulipiridwa.
Keloid ya postoperative padzanja yomwe idathandizidwa ndi jakisoni wa triamcinolone intralesional. Dera lomwe lamira la erythema kumanzere ndilo malo ochiritsidwa.
Linear Keloids. Zikafika kutsogolo kumtunda kwa torso, nthawi zambiri zimawonekera mozungulira.
Keloid yapambuyo pamtima
Keloids pamapazi sangakhale omasuka kuyenda.Majekeseni a Intralesional steroid nthawi zambiri amachitidwa kangapo.
Keloids nthawi zambiri amawonedwa pamikono yakumtunda.
Chiwonetsero chodziwika bwino cha chifuwa keloids.
References
Keloids amapanga chifukwa cha machiritso achilendo pambuyo povulala pakhungu kapena kutupa. Zinthu zachibadwa komanso zachilengedwe zimathandizira kukula kwawo, ndipo kuchuluka kwa anthu akhungu lakuda ndi ochokera ku Africa, Asia, ndi Hispanic. Keloids imachitika pamene ma fibroblasts ayamba kugwira ntchito mopitirira muyeso, kutulutsa kolajeni wochuluka ndi zinthu za kukula. Izi zimabweretsa kupanga mitolo yayikulu, yosadziwika bwino ya collagen yotchedwa keloidal collagen, komanso kuchuluka kwa ma fibroblasts. Kachipatala, ma keloid amawoneka ngati tinthu tating'onoting'ono tolimba m'malo ovulala kale. Mosiyana ndi zipsera wamba, keloid amapitilira kupitilira malo ovulalawo. Odwala amatha kumva kuwawa, kuyabwa, kapena kuyaka. Mankhwala osiyanasiyana alipo, kuphatikizapo jakisoni wa steroid, cryotherapy, opaleshoni, radiotherapy, ndi laser therapy.
Keloids result from abnormal wound healing in response to skin trauma or inflammation. Keloid development rests on genetic and environmental factors. Higher incidences are seen in darker skinned individuals of African, Asian, and Hispanic descent. Overactive fibroblasts producing high amounts of collagen and growth factors are implicated in the pathogenesis of keloids. As a result, classic histologic findings demonstrate large, abnormal, hyalinized bundles of collagen referred to as keloidal collagen and numerous fibroblasts. Keloids present clinically as firm, rubbery nodules in an area of prior injury to the skin. In contrast to normal or hypertrophic scars, keloidal tissue extends beyond the initial site of trauma. Patients may complain of pain, itching, or burning. Multiple treatment modalities exist although none are uniformly successful. The most common treatments include intralesional or topical steroids, cryotherapy, surgical excision, radiotherapy, and laser therapy.
Keloids result from abnormal wound healing in response to skin trauma or inflammation. Keloid development rests on genetic and environmental factors. Higher incidences are seen in darker skinned individuals of African, Asian, and Hispanic descent. Overactive fibroblasts producing high amounts of collagen and growth factors are implicated in the pathogenesis of keloids. As a result, classic histologic findings demonstrate large, abnormal, hyalinized bundles of collagen referred to as keloidal collagen and numerous fibroblasts. Keloids present clinically as firm, rubbery nodules in an area of prior injury to the skin. In contrast to normal or hypertrophic scars, keloidal tissue extends beyond the initial site of trauma. Patients may complain of pain, itching, or burning. Multiple treatment modalities exist although none are uniformly successful. The most common treatments include intralesional or topical steroids, cryotherapy, surgical excision, radiotherapy, and laser therapy.
Kafukufuku waposachedwa akuwonetsa kuti gel osakaniza a silicone kapena sheeting limodzi ndi jakisoni wa corticosteroid ndiye chithandizo choyambirira chomwe chimakondedwa kwambiri ndi keloids. Mankhwala owonjezera monga intralesional 5-fluorouracil (5-FU) , bleomycin, kapena verapamil amathanso kuganiziridwa, ngakhale kuti mphamvu zake zimasiyana. Mankhwala a laser, akaphatikizidwa ndi jakisoni wa corticosteroid kapena topical steroids pansi pa occlusion, amatha kupititsa patsogolo kulowa kwa mankhwala. Kwa recalcitrant keloids, kuchotsedwa kwa opaleshoni komwe kumatsatiridwa ndi chithandizo chamankhwala chanthawi yomweyo kwawonetsa kuti ndi kothandiza. Pomaliza, kugwiritsa ntchito silicone sheeting ndi kukakamiza mankhwala kwatsimikiziridwa kuti kumachepetsa mwayi wobwereza keloid.
Current literature supports silicone gel or sheeting with corticosteroid injections as first-line therapy for keloids. Adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil can be considered, although mixed results have been reported with each. Laser therapy can be used in combination with intralesional corticosteroids or topical steroids with occlusion to improve drug penetration. Excision of keloids with immediate post-excision radiation therapy is an effective option for recalcitrant lesions. Finally, silicone sheeting and pressure therapy have evidence for reducing keloid recurrence.
Current literature supports silicone gel or sheeting with corticosteroid injections as first-line therapy for keloids. Adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil can be considered, although mixed results have been reported with each. Laser therapy can be used in combination with intralesional corticosteroids or topical steroids with occlusion to improve drug penetration. Excision of keloids with immediate post-excision radiation therapy is an effective option for recalcitrant lesions. Finally, silicone sheeting and pressure therapy have evidence for reducing keloid recurrence.
Pakadali pano, palibe chithandizo chamtundu umodzi chomwe chimatsimikizira kuti ma keloid amakhalanso otsika. Komabe, zosankha zomwe zikukulirakulira, monga kugwiritsa ntchito ma lasers pamodzi ndi ma steroids kapena kuphatikiza 5-fluorouracil ndi ma steroids, zikuwonetsa zabwino. Kafukufuku wamtsogolo angayang'ane kwambiri momwe mankhwala atsopano, monga autologous mafuta Ankalumikiza kapena stem cell-based therapy, amagwirira ntchito kuyang'anira keloids.
There continues to be no gold standard of treatment that provides a consistently low recurrence rate; however the increasing number of available treatments and synergistic combinations of these treatments (i.e., laser-based devices in combination with intralesional steroids, or 5-fluorouracil in combination with steroid therapy) is showing favorable results. Future studies could target the efficacy of novel treatment modalities (i.e., autologous fat grafting or stem cell-based therapies) for keloid management.
There continues to be no gold standard of treatment that provides a consistently low recurrence rate; however the increasing number of available treatments and synergistic combinations of these treatments (i.e., laser-based devices in combination with intralesional steroids, or 5-fluorouracil in combination with steroid therapy) is showing favorable results. Future studies could target the efficacy of novel treatment modalities (i.e., autologous fat grafting or stem cell-based therapies) for keloid management.
Zipsera ndi gawo lofala la machiritso pambuyo povulala pakhungu. Moyenera, zipsera ziyenera kukhala zosalala, zopyapyala, ndi zofanana ndi khungu. Zinthu zambiri zingapangitse kuti chilonda chisachiritsidwe bwino, monga matenda, kuchepa kwa magazi, ischemia, ndi kuvulala. Zipsera zomwe zimakhala zokhuthala, zakuda kuposa khungu lozungulira, kapena zocheperachepera zimatha kuyambitsa zovuta zokhudzana ndi thupi komanso thanzi lamalingaliro.
Scars are a natural and normal part of healing following an injury to the integumentary system. Ideally, scars should be flat, narrow, and color-matched. Several factors can contribute to poor wound healing. These include but are not limited to infection, poor blood flow, ischemia, and trauma. Proliferative, hyperpigmented, or contracted scars can cause serious problems with both function and emotional well-being.
Scars are a natural and normal part of healing following an injury to the integumentary system. Ideally, scars should be flat, narrow, and color-matched. Several factors can contribute to poor wound healing. These include but are not limited to infection, poor blood flow, ischemia, and trauma. Proliferative, hyperpigmented, or contracted scars can cause serious problems with both function and emotional well-being.
Zipsera za Keloid zimawoneka kawirikawiri mwa anthu a ku Africa, Asia, kapena Puerto Rico. Anthu azaka zapakati pa 10 ndi 30 ali ndi chizolowezi chokulitsa keloid kuposa okalamba.
Ngakhale nthawi zambiri zimachitika pamalo ovulala, keloid imathanso kubwera yokha. Zitha kuchitika pamalo oboola komanso kuchokera ku chinthu chosavuta monga pimple kapena zokanda. Zitha kuchitika chifukwa cha ziphuphu zazikulu kapena zipsera za nkhuku, matenda pabalaza, kuvulala kobwerezabwereza kudera, kupsinjika kwambiri pakhungu pakutseka kwa bala kapena thupi lachilendo pabala.
Zipsera za Keloid zimatha kuchitika pambuyo pa opaleshoni. Zimapezeka kwambiri m'malo ena, monga pachifuwa chapakati (kuchokera ku sternotomy), msana ndi mapewa (kawirikawiri zimachitika chifukwa cha ziphuphu), ndi nsonga za makutu (zoboola makutu). Zitha kuchitikanso pakuboola thupi. Mawanga odziwika kwambiri ndi makutu, mikono, dera la pelvic, komanso pamwamba pa fupa la kolala.
Mankhwala omwe alipo ndi kuponderezana, silicone gel sheeting, intra-lesional triamcinolone acetonide, cryosurgery, radiation, laser therapy, Interferon, 5-FU ndi kudulidwa kwa opaleshoni.
○ Machiritso
Zipsera za hypertrophic zimatha kukhala bwino ndi jakisoni wa 5 mpaka 10 wa intralesional steroid mwezi umodzi.
#Triamcinolone intralesional injection
Chithandizo cha laser cha erythema chokhudzana ndi chipsera chikhoza kuyesedwa, koma jakisoni wa triamcinilone amathanso kuwongolera erythema mwa kufewetsa chilondacho.
#Dye laser (e.g. V-beam)