Prurigo nodularis
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ReferencesPrurigo nodularis ndi khungu lokhalitsa kwanthawi yayitali, lomwe limadziwika ndi ziphuphu zambiri zolimba komanso tinthu tating'onong'ono, zomwe nthawi zambiri zimapezeka kunja kwa mikono ndi miyendo. Ziphuphuzi zimatha kukhala zamitundu yosiyanasiyana, kuyambira thupi mpaka pinki, ndipo zimakhala zoyabwa kwambiri. Zitha kukhudza aliyense, ndipo nthawi zambiri zimakhala ndi chikhalidwe cha khungu, monga atopic dermatitis, chomwe chimayambitsa kuyabwa kosatha. Njira zothetsera zimaphatikizapo mankhwala amphamvu oletsa kuyabwa, mankhwala omwe amathandiza chitetezo cha thupi, ndi mankhwala omwe amawonjezera mphamvu ya mitsempha. Kusamalira prurigo nodularis nthawi zambiri kumafuna chithandizo cha nthawi yayitali.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Chithandizo nthawi zambiri chimaphatikizapo kugwiritsa ntchito mafuta odzola kapena jakisoni ya ma steroid pamalo okhudzidwa. Pazovuta kapena zovuta kwambiri, chithandizo cha mankhwala chopepuka kapena mankhwala omwe amalepheretsa chitetezo chamthupi chingafunike. Thalidomide ndi lenalidomide ndizosankhidwa pazochitika zazikulu, koma zimatha kukhala ndi zotsatira zoyipa. Mankhwala atsopano (opioid receptor antagonists, neurokinin-1 receptor antagonists) amawonetsa lonjezo pochiza prurigo nodularis ndi zotsatira zochepa poyerekeza ndi thalidomide kapena lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo ndi khungu lomwe limadziwika ndi kuyabwa kwa thupi yayitali (kupitilira milungu 6), zotupa zokhudzana ndi kukanda, komanso mbiri yakukanda pafupifupi. Zimaphatikizapo neuroinflammation ndi fibrosis pakhungu.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis ndi vuto la khungu lokhalitsa lomwe limadziwika ndi ma nodule oyabwa. Sitikudziwa chomwe chimayambitsa matenda awa, koma zikuwoneka kuti mavuto a chitetezo cha thupi ndi mitsempha zimathandizira kuti pakhale ngozi. Pakadali pano, palibe mankhwala aliwonse omwe amavomerezedwa ndi US FDA makamaka pa prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Chithandizo ― OTC Mankhwala
Kutsuka malo otupa ndi sopo sikuthandiza, ndipo kumatha kuipiraipira. Mafuta a OTC steroid angathandize kuchepetsa zizindikiro, koma nthawi zambiri amafunika kutseka kwa masabata angapo kuti asinthe. Kupitiliza kumwa antihistamines kumathandizanso kuchepetsa kuyabwa.
#OTC steroid ointment
#OTC antihistamine
○ Machiritso
#Intralesional triamcinolone injection