Urticaria pigmentosa
Urticaria pigmentosa ndi mtundu wofala kwambiri wa cutaneous mastocytosis. Ndi matenda osowa kwambiri omwe amayamba chifukwa cha kuchuluka kwa mast cell pakhungu omwe amapanga ming'oma kapena zotupa pakhungu zikakwiya. Mawanga ofiira kapena ofiirira nthawi zambiri amawoneka pakhungu, nthawi zambiri kuzungulira pachifuwa, pamphumi, ndi kumbuyo. Maselo a mast awa, akakwiya (monga kupukuta khungu, kutentha kwa kutentha), amatulutsa histamine yochuluka kwambiri, yomwe imayambitsa chisokonezo chomwe chimatsogolera ku ming'oma yomwe imapezeka kudera lakupsa mtima, nthawi zina amatchedwa "chizindikiro cha Darier".
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References
Mastocytosis ndi mkhalidwe womwe pamakhala kuchuluka kwa mast cell, omwe nthawi zambiri amapezeka m'zigawo zosiyanasiyana za thupi monga khungu, m'mafupa, komanso m'mimba. Malinga ndi World Health Organisation (WHO) , cutaneous mastocytosis ikhoza kugawidwa m'magulu atatu akuluakulu. Mtundu woyamba (mastocytomas) umakhala ndi zotupa zokha kapena zochepa (≤3) . Mtundu wachiwiri (urticaria pigmentosa) umaphatikizapo zilonda zambiri, zomwe zimayambira pa 10 mpaka zosachepera 100. Mtundu wotsiriza umasonyeza kukhudzidwa kwakukulu pakhungu. Urticaria pigmentosa ndi mtundu wofala kwambiri wa cutaneous mastocytosis mwa ana, koma umapezekanso mwa akulu. Nthawi zambiri ndi vuto lopanda vuto lomwe nthawi zambiri limakhala bwino paunyamata. Mosiyana ndi mastocytosis wamkulu, urticaria pigmentosa sizikhudza kwambiri ziwalo zamkati. Chinthu chimodzi chodziwika bwino cha urticaria pigmentosa ndi chizolowezi chake choyambitsa mawanga ang'onoang'ono, oyabwa, ofiira-bulauni, kapena chikasu chabulauni pakhungu, zomwe zimadziwika kuti ming'oma. Mawangawa nthawi zambiri amawonekera ali mwana ndipo amatha kukhala moyo wonse.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mtsikana wina wazaka 6 anabwera ali ndi madontho angapo amtundu wakuda omwe amayamba kuoneka pamutu pake ndipo amafalikira kumaso ndi thupi lake miyezi isanu ndi umodzi yapitayi. Adanenanso kuti amawuka, amasanduka ofiira, komanso kuyabwa akakakamizidwa. Sanamve kutentha, kusanza, kutsekula m'mimba, kapena kupuma, ndipo mbiri yake yachipatala komanso yabanja silinapereke zidziwitso zoyenera. Titamuyesa, tidapeza madontho akuda angapo pamutu pake, pamphumi, kumaso, ndi khosi, komanso zigamba zakuda zokwezeka pang'ono pachifuwa ndi kumsana. Kupaka mawangawo pang'ono kumapangitsa kutupa ndi kuyabwa mkati mwa mphindi ziwiri, koma zizindikirozo zidazimiririka mkati mwa mphindi 15-20 (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
