Porokeratosis
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د آلمان څخه د 2022 سټیفټنګ وارینسټ پایلو کې ، د ماډلډرم سره د مصرف کونکي رضایت د تادیه شوي ټیلی میډیسن مشورې په پرتله یوازې یو څه ټیټ و.
د آلمان څخه د 2022 سټیفټنګ وارینسټ پایلو کې ، د ماډلډرم سره د مصرف کونکي رضایت د تادیه شوي ټیلی میډیسن مشورې په پرتله یوازې یو څه ټیټ و.
سخت خپریدونکي څنډې ځانګړتیاوې لري.
relevance score : -100.0%
ReferencesPorokeratosis د پوستکي یو نادر حالت دی چې د keratinization ستونزې له امله رامنځته کېږي، او په پایله کې د پوستکي ګوتې یا خړوبونه جوړېږي. د مایکروسکوپ لاندې د دې ځانګړې نښې د کورنایډ لامیلا شتون دی، چې د پوستکي په پورتنۍ طبقه کې د حجرو ځانګړی ترتیب ښیي. Porokeratosis په مختلفو بڼو کې راځي (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). دا مهمه ده چې په یاد ولرئ چې Porokeratosis ممکن د پوستکي سرطان خطر زیات کړي. د Porokeratosis تشخیص لپاره غوره لاره د متاثرې ساحې بایوپسي ده، که څه هم اوس مهال د درملنې معیاري پروتوکول شتون نلري.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) د keratinization ګډوډۍ ناروغي ده. دا د پوروکیراټوسس له شپږو ډولونو څخه یو دی او عموماً د نورو په پرتله په لویو برخو کې څرګندېږي (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). د پوروکیراټوسس د سوځیدنې ډول اکثره د سرطان، کمزورې معافیت یا التهاب سره تړاو لري. د خطر فکتورونه جینیتیک عوامل، د معافیت کمزوري، او د لمر سره تماس شامل دي. DSAP د ګلابي یا نسواري ډنډونو په بڼه پیل کېږي، چې عموماً په لمر ته ډېرې حساس سیمو کې څرګندېږي؛ کله‑کله لږ خارش هم رامنځته کوي. درملنه متنوعه ده او کېدای شي موضعي کریمونه، رڼا درملنه، یا درمل لکه 5-fluorouracil یا retinoids شامل وي. دا زخمونه د مخکینۍ ناروغۍ په توګه ګڼل کېږي؛ د 7.5‑10 ٪ چانس شته چې په squamous cell یا basal cell carcinoma بدلېږي.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
یو 52 کلن سړی چې دمخه روغ و، د څلورمې پښې په پای کې د حلقوي شکل لرونکي پیچ سره مخ شو، کوم چې د دوو کلونو لپاره پرته له کومې نښې شتون درلود. دا ابتداً د کوچني، سخت ډنډ په توګه پیل شو او د وخت په تیریدو سره وده وکړه. د مختلفو درملنو لکه کریوتراپي، کریمونه، انټي‑فنګسونه او انټي‑بیوټیکونه کارولو سره هم، پیچ ښه نه شو. د ډرموکوپسي په نږدې معاینه کې یو وچ، سور مرکز د موټی او خراب سرحد سره وموندل شو. د پوستکي یوه کوچنۍ ټوټه چې د پیچ له څنډې څخه اخیستل شوې، په پوستکي د بهرنۍ طبقې غیر معمولي حجرو وده ښودله، چې د porokeratosis of Mibelli تشخیص تاییدوي.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
ډېر وخت بایوپسي ترسره کېږي ځکه چې دا د اکټینیک کیراټوسس یا squamous cell carcinoma سره ورته ښکاري.