Porokeratosis
☆ د آلمان څخه د 2022 سټیفټنګ وارینسټ پایلو کې ، د ماډلډرم سره د مصرف کونکي رضایت د تادیه شوي ټیلی میډیسن مشورې په پرتله یوازې یو څه ټیټ و.
سخته خپریدونکي څنډې ځانګړتیاوې لري.
References
Porokeratosis د پوستکي یو نادر حالت دی چې د keratinization ستونزې لخوا مشخص کیږي، چې په پایله کې یې د پوستکي د ګوتو په شکل یا د پوټکي خړوبونه پورته کیږي. د مایکروسکوپ لاندې د دې مشخص ځانګړتیا د کورنایډ لامیلا شتون دی، د پوستکي په پورتنۍ طبقه کې د حجرو ځانګړی ترتیب. Porokeratosis په مختلفو بڼو کې راځي (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . دا مهمه ده چې په یاد ولرئ چې porokeratosis کولی شي په احتمالي توګه د پوستکي سرطان ته وده ورکړي. د porokeratosis د تشخیص غوره لاره د پورته شوي سرحد د بایپسي له لارې ده، که څه هم اوس مهال د درملنې معیاري پروتوکول شتون نلري.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) د keratinization ګډوډۍ ناروغي ده. دا د پوروکیراټوسس له شپږو ډولونو څخه یو دی، او دا معمولا د نورو په پرتله په لویو برخو اغیزه کوي (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . د پوروکیراټوسس د سوځیدنې ډول اکثرا د سرطان، کمزوری معافیت، یا التهاب سره تړاو لري. د خطر فکتورونه جینیات، د معافیت فشار، او د لمر افشا کول شامل دي. DSAP د ګلابي یا نسواري ډنډونو په توګه پیل کیږي چې د لمر په تودو سیمو کې د پورته کنډونو سره، ځینې وختونه د لږ خارش لامل کیږي. درملنه توپیر لري او کېدی شي اصلي کریمونه، رڼا درملنه، یا درمل لکه 5-fluorouracil یا retinoids شامل وي. دا زخمونه مخکینۍ ناروغۍ ګڼل کیږي، د 7. 5 - 10 % چانس په squamous cell یا basal cell carcinoma باندې بدلیږي.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
یو 52 کلن سړی چې دمخه روغ و ، د هغه د څلورمې پښې په پای کې د حلقوي شکل لرونکي پیچ سره راغی ، کوم چې د 2 کلونو لپاره پرته له کومې نښې پرته شتون درلود. دا د کوچني، سخت ډنډ په توګه پیل شو او د وخت په تیریدو سره بهر ته وده ورکړه. د مختلفو علاجونو لکه کریوتراپي، کریمونو، انټي فنګسونو، او انټي بیوټیکونو هڅه کولو سره سره، پیچ ښه نه شو. د ډرموکوپسي سره نږدې معاینه کول یو وچ، سور مرکز وښوده چې یو موټی، خراب سرحد لري. د پوستکي یوه کوچنۍ ټوټه د پیچ له څنډې څخه اخیستل شوې د پوستکي په بهرنۍ طبقه کې د غیر معمولي حجرو وده ښودلې، چې د porokeratosis of Mibelli تشخیص تاییدوي.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
ډیری وختونه بایپسي ترسره کیږي ځکه چې دا د اکټینیک کیراټوسس یا squamous cell carcinoma سره ورته ښکاري.