Amyloidosis - Amiloidose
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Nos resultados do Stiftung Warentest de 2022 da Alemanha, a satisfação do consumidor com o ModelDerm foi apenas ligeiramente inferior do que com as consultas pagas de telemedicina.
Nos resultados do Stiftung Warentest de 2022 da Alemanha, a satisfação do consumidor com o ModelDerm foi apenas ligeiramente inferior do que com as consultas pagas de telemedicina.
Características faciais clássicas da Amiloidose (Amyloidosis)
relevance score : -100.0%
ReferencesUma mulher de 26 anos procurou nossa clínica queixando‑se de erupção cutânea com comichão nas pernas, presente há 10 anos. Apesar de usar cremes esteroides e creme de tazaroteno, a lesão não melhorou. Ela não tinha histórico familiar relevante. Ao examiná‑la, observamos manchas ásperas e salientes na parte frontal das pernas, que correspondiam a uma condição chamada lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis é uma doença cutânea rara, associada a coceira persistente de causa desconhecida. Normalmente se apresenta como aglomerados de manchas elevadas e descoloridas nas superfícies externas da pele. A Lichen Amyloidosis costuma surgir em pessoas entre 50 e 60 anos e, infelizmente, não há cura. Os tratamentos atualmente disponíveis geralmente não são muito eficazes.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis é uma condição de pele com coceira crônica. É caracterizada por aglomerados de nódulos espessos encontrados principalmente nas costas, canelas, coxas e braços. Ao ser examinado ao microscópio, Lichen amyloidosis mostra acúmulo de amiloide na camada superior da pele, associado ao espessamento da camada externa. Embora a causa exata do Lichen amyloidosis ainda não seja totalmente compreendida, estudos anteriores associaram‑no a fatores como fricção na pele, morte celular, infecções virais, entre outros. Lichen amyloidosis parece estar relacionado a várias outras doenças de pele, como atopic dermatitis, lichen planus e mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnóstico e Tratamento
#Electrophoresis of blood or urine
#Skin biopsy