Porokeratosis - Poroceratose
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Nos resultados do Stiftung Warentest de 2022 da Alemanha, a satisfação do consumidor com o ModelDerm foi apenas ligeiramente inferior do que com as consultas pagas de telemedicina.
Nos resultados do Stiftung Warentest de 2022 da Alemanha, a satisfação do consumidor com o ModelDerm foi apenas ligeiramente inferior do que com as consultas pagas de telemedicina.
As bordas duras e salientes são características.
relevance score : -100.0%
ReferencesPorokeratosis é uma doença rara da pele caracterizada por problemas de queratinização, resultando em manchas salientes em forma de anel ou lesões hiperqueratósicas ou semelhantes a verrugas na pele. Sua característica definidora ao microscópio é a presença da lamela cornoide (cornoid lamella), um arranjo específico de células na camada superior da pele. Porokeratosis vem em vários formatos, como poroceratose actínica superficial disseminada (disseminated superficial actinic porokeratosis), poroceratose clássica de Mibelli (classical porokeratosis of Mibelli), poroceratose palmar e plantar disseminada (porokeratosis palmaris plantaris et disseminatum) e poroceratose linear (linear porokeratosis). É importante observar que porokeratosis pode potencialmente evoluir para câncer de pele. A melhor maneira de diagnosticar porokeratosis é através de uma biópsia da borda elevada, embora atualmente não exista um protocolo de tratamento padrão.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) é uma doença de queratinização desordenada. É um dos seis tipos de poroceratose (porokeratosis) e geralmente afeta áreas maiores em comparação com os outros (linear (linear), Mibelli (Mibelli), punctate (punctate), poroceratose palmar e plantar disseminada (palmoplantar disseminated) e poroceratose superficial (superficial porokeratosis)). O tipo eruptivo de poroceratose (porokeratosis) geralmente está associado ao câncer, imunossupressão ou inflamação. Os fatores de risco envolvem genética, supressão imunológica e exposição solar. O DSAP começa como inchaços rosados ou marrons com bordas elevadas em áreas expostas ao sol, às vezes causando leve coceira. Os tratamentos variam e podem incluir cremes tópicos, fototerapia ou medicamentos como 5‑fluorouracil ou retinóides. Essas lesões são consideradas pré‑cancerosas, com 7,5‑10 % de chance de se transformarem em carcinoma de células escamosas (squamous cell carcinoma) ou carcinoma basocelular (basal cell carcinoma).
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Um homem de 52 anos, previamente saudável, apresentou uma placa annular atrófica na porção distal do quarto dedo do pé, assintomática, com duração de 2 anos. A lesão começou como uma pequena pápula queratinosa que gradualmente aumentou de forma centrífuga. Ele recebeu múltiplos tratamentos, incluindo crioterapia, corticosteroides tópicos, antifúngicos e antibióticos, sem melhora. O exame dermatoscópico revelou uma área central escamosa, atrófica e eritematosa, com uma borda periférica hiperqueratósica bem delimitada. Uma biópsia cutânea da borda da lesão mostrou uma lamela cornoide com coluna de células paraceratóticas provenientes de uma invaginação da epiderme e ausência da camada granular. A correlação clínico‑patológica foi consistente com poroceratose de Mibelli (porokeratosis of Mibelli).
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Freqüentemente, uma biópsia é realizada porque pode ser semelhante à ceratose actínica ou ao carcinoma de células escamosas.