Syphilis - Sífilis
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Chancres ― infecção sifilítica primária por Treponema pallidum
relevance score : -100.0%
ReferencesA sífilis é uma doença sexualmente transmissível causada pela bactéria Treponema pallidum. Neste estudo, focamos em 57 pacientes, com idades entre 18 e 68 anos, com sífilis secundária.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
A sífilis é uma infecção bacteriana causada pelo Treponema pallidum. Pode imitar diversas doenças, ganhando o apelido de great imitator. A sífilis ainda afeta milhões de pessoas em todo o mundo, mas pode ser tratada eficazmente com penicilina.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum causa sífilis por contato sexual ou de mãe para filho durante a gestação. Embora existam testes simples para diagnosticá‑la e o tratamento com uma dose única de penicilina de ação prolongada seja eficaz, a sífilis está voltando a ser um grande problema mundial. Isso é particularmente verdadeiro entre homens que fazem sexo com homens (HSH) em países de alta e média renda. Embora alguns países de baixa renda tenham atingido as metas da OMS para impedir a transmissão da sífilis da mãe para o bebê, observa‑se um aumento preocupante da sífilis entre HSH seropositivos.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Fígado aumentado: é um achado frequente e pode ocorrer associado a baço aumentado. A biópsia hepática examinada ao microscópio de campo escuro pode revelar a presença da espiroqueta. Os testes de função hepática podem apresentar alterações. (2) Amarelecimento da pele (icterícia): a presença de icterícia depende do grau de comprometimento hepático. (3) Corrimento nasal: costuma ser um dos primeiros sinais, aparecendo geralmente na primeira semana de vida. (4) Gânglios linfáticos inchados: o aumento generalizado dos gânglios linfáticos, geralmente indolor, é comum. (5) Erupção cutânea: costuma surgir de uma a duas semanas após o corrimento nasal. São observadas pequenas manchas vermelhas ou rosadas nas costas, nádegas, coxas e solas dos pés. A erupção pode evoluir para descamação e formação de crostas.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnóstico e Tratamento
VDRL e RPR podem ser usados para detectar infecção recente e monitorar a doença. O teste FTA‑ABS é mais específico e pode ser utilizado para confirmar infecções anteriores. A penicilina é o tratamento de escolha para a sífilis.