Angiofibroma - Angiofibrom
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References
Cutaneous angiofibromas poate apărea în diferite părți ale corpului. Pe față, ele sunt adesea cunoscute ca papule fibroase sau adenom sebaceum; pe penis, se numesc pearly penile papules ; sub unghie, ele sunt denumite angiofibroame periungale sau tumori Koenen; iar în gură, sunt denumite fibroame orale. Angiofibroamele faciale sunt o caracteristică proeminentă a tuberous sclerosis (TS) , o tulburare moștenită care afectează pielea, rinichii, inima, creierul și plămânii. Ele se dezvoltă de obicei pe față în timpul copilăriei sau la vârsta adultă timpurie la persoanele cu ST. A avea trei sau mai multe angiofibroame faciale sau două sau mai multe angiofibroame periungale este considerată semnificativă în diagnosticarea TS. În plus, angiofibroamele faciale multiple pot fi prezente în condiții (multiple endocrine neoplasia type 1 (MEN-1) și Birt-Hogg-Dubé syndrome) . Pearly penile papules se găsesc de-a lungul marginii coronare și a șanțului penisului. Sunt umflături persistente, nedureroase, observate mai frecvent la bărbații necircumciși.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
1) fata
Fibrous papule
2) penisul
Pearly penile papule
3) sub unghia de la mâini sau de la picioare
Periungual angiofibroma